Micromass UK Limited

Merck Sharp + Dohme Corp.

Jose M Castro-Perez

Robert Stephen Plumb

Alan Millar

Songnian Lin

Yusheng Xiong

Harry R Davis

Hong-Ping Guan

Thomas P Roddy

Liangsu Wang

Samuel E Engel

Sheng-Ping Wang

Jane Kirby

Douglas G Johns

John Philip Edward Shockcor

Stephen F Previs

Samuel S Engel

John Schockcor

Steven F Previs

Robert Plumb

Use of a glucagon receptor antagonist in combination with a cholesterol absorption inhibitor for the treatment of diabetes and related conditions is disclosed.

Methods of treating diabetes by administering a glucagon receptor antagonist in combination with a cholesterol absorption inhibitor

A method of searching for potentially unknown metabolites of pharmaceutical compounds is disclosed. The accurate mass of a pharmaceutical compound will generally be known and can be rendered in the form of an integer nominal mass or mass to charge ratio component and a decimal mass or mass to charge ratio component. Possible metabolites are searched for on the basis of having a decimal mass or mass to charge ratio component which is substantially very similar to the decimal mass or mass to charge ratio of the parent pharmaceutical compound.

Mass spectrometry

A mass spectrometer comprising a collision, fragmentation or reaction cell () is disclosed. The collision, fragmentation or reaction cell () is repeatedly switched back and forth between a high fragmentation mode of operation and a low fragmentation mode of operation. Mass spectral data sets are obtained in both modes of operation. A decimal mass filter is applied to one or both sets of data. In particular, fragment ions or metabolites related to a parent or precursor ion of interest are identified on the basis of having a decimal mass which is similar to that of the parent or precursor ion of interest.

Mass spectrometer

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New Providence, NJ, United States of America

Jose M Castro-Perez