The United States of America, as Represented by the Secretary, Department of Health and Human Services

Other

Fundacao Oswaldo Cruz-Fiocruz

University of California

Jose M C Ribeiro

Jesus G Valenzuela

Claudia I Brodskyn

Regis Gomes

Aldina Barral

Manoel Barral Netto

Shaden Kamhawi

Ivo M Francischetti

Yasmine Belkaid

David Sacks

Eric Calvo

Osvaldo Marinotti

Eddie Wayne Cupp

Mary Smith Cupp

Substantially purified salivarypolypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including thepolynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventingare disclosed.

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The present invention relates to the discovery of the Aegyptin gene and Aegyptin protein, a molecule that interacts with collagen and inhibits platelet adhesion, activation and aggregation. Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed.

Aegyptin and uses thereof

Substantially purified salivarypolypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including thepolynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed.

Lutzomyia longipalpis polypeptides and methods of use

The present invention provides methods of selecting and uses of anti-arthropod vector vaccines to prevent Leishmaniasis. The present invention also provides compositions for vaccines to prevent Leishmaniasis.

Anti-arthropod vector vaccines, methods of selecting and uses thereof

Anti-arthropod vector vaccines method of selecting and uses thereof

The invention is drawn to vasodilative proteins from the salivary glands of the species, Simulium. The protein additionally has immunomodulating activities. Methods for recombinant production of the protein as well as biomedical uses are provided.

Methods of use of recombinant vasoactive protein from salivary gland of the black fly

Recombinant vasoactive protein from salivary gland of the black fly

Growing community of inventors

Rockville, MD, United States of America

Jose M C Ribeiro