Pharma Mar, S.a.

Instituto Biomar, S.a.

Universidad De Cádiz

Jose Luis Fernandez Puentes

Dolores Garcia Gravalos

Ana Rodriguez Quesada

Tatsuo Higa

Javier Salva

Eva Zubia

Santiago Naranjo Lozano

Rosario Duran

Maria J Ortega

Naturally occurring stolonoxide compounds, and derivatives thereof, have antitumor activity. Typical compounds are of the formula (I) or a derivative thereof 

Stolonoxides

Cytotoxic tris(oxazole)-containing macrolides

The lamellarin compounds disclosed herein have been found to be inhibitors of MDR, i.e., acquired multidrug resistance, which has become a major problem in the treatment of various cancers. The lamellarin compounds disclosed herein have also been found to be cytotoxic to MDR cells. MDR is believed to be associated with certain alterations in tumor cells, including an over-expression of a certain high molecular weight membrane glycoprotein and a decrease in the ability of the tumor cell to accumulate and retain chemotherapeutic agents. The present invention is thus directed to methods of treating MDR-type tumors with an effective anti-MDR amount (either inhibitory or cytotoxic) of one or more lamellarin compounds, which compounds have been found to be effective antitumoral agents against MDR cells.

Methods of treatment using lamellarin-class alkaloids

Growing community of inventors

Leon, Spain

Jose Luis Fernandez Puentes