Consejo Superior De Investigaciones Cientificas

Nanodreams, S.l.

Jose Jaime Ruz Martinez

Francisco Javier Tamayo De Miguel

Priscila Monteiro Kosaka

Valerio Pini

Daniel Ramos Vega

Oscar Malvar Vidal

Montserrat Calleja Goméz

Maria Ujue Gonzalez Sagardoy

Mario Encinar Del Pozo

Javier Tamayo De Miguel

Eduardo Gil Santos

The present invention relates to a system for biodetection applications comprising two basic elements, a substrate with a functionalized surface and a nanoparticle, the system being capable of enhancing the plasmonic effect of the nanoparticle. The invention also relates to a biosensor incorporating such system, in addition to the method for detecting and quantifying a target analyte selected in a sample using such system. Finally, the invention relates to a device which can detect the enhanced optoplasmonic effect of the nanoparticles by means of the system of the invention or by combining the detection of such optoplasmonic effect with the analysis of the changes in the mechanical characteristics in the substrate.

System for biodetection applications

A method for obtaining the absorption position, mass and rigidity of a particle deposited on the surface of a resonator based on the relative change in the resonance frequency of said resonator in 3 or 4 flexural vibration modes. The rigidity of the particles is of great interest in the study of cells and other biological compounds that change state without significantly changing the mass.

Method for obtaining the absorption position, mass and rigidity of a particle

The invention relates to a spectrophotometer, especially a spectrophotometer that can carry out simultaneous analysis at different points on the same sample (), with a high spatial resolution and without requiring a mechanical system for physical scanning along the sample. This is obtained by the provision of means for processing the light received by the photodetectors (), said processing means having a correlation wherein each of the photodetectors () corresponds to a spatial point on the sample (). In the case of dark field applications, the present invention ensures the standardization of the data using the same measure.

Spectrophotometer

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Madrid, Spain

Jose Jaime Ruz Martinez