Centro De Ingenieria Genetica Y Biotecnologia

Jose Ignacio Fernandez Montequin

Gerardo Enrique Guillen Nieto

Jorge Amador Berlanga Acosta

Luis Saturnino Herrera Martinez

Diana Garcia Del Barco Herrera

Sonia Gonzalez Blanco

Danay Cibrian Vera

Raimundo Ubieta Gomez

Vivian Maria Saez Martinez

Haydee Geronimo Perez

Jorge Sotolongo Pena

Hector Santana Milian

Ingrid Rojas Constantin

Calixto Valdes Perez

Neobalis Franco Perez

Larissa Chacon Corvea

Leonardo Canan-Haden Frias

The present invention is relevant to human medicine, and, in particular, to the use of Epidermal Growth Factor (EGF) in a pharmaceutical composition, said composition is administered through infiltration at the periphery of nerve trunks and/or ganglia, for the morphofunctional restoration of peripheral nerves in painful, sensory-motor neuropathy, as well as ischemic neuritis. It is also relevant to an EGF containing composition, where this molecule can be formulated together with anesthetic or analgesic drugs, or encapsulated in microspheres, and their use for the morphofunctional restoration of peripheral nerves in painful, sensory-motor neuropathy, as well as in ischemic neuritis.

Use of epidermal growth factor for the morphofunctional restoration of peripheral nerves in diabetic neuropathy

The invention relates to human medicine and to the use of epidermal growth factor (EGF) for preparing a pharmaceutical composition which is administered by infiltration into the periphery of nerve ganglia and/or trunks for the morphofunctional restoration of peripheral nerves in painful sensory-motor neuropathy as well as manifestations of ischemic neuritis. The invention also includes a composition containing EGF which can be formulated together with anesthetics or analgesics or encapsulated in microspheres and to the use thereof for the morphofunctional restoration of peripheral nerves in painful sensitive-motor-type diabetic neuropathy and the manifestations of ischemic neuritis.

The invention relates to the use of Epidermal Growth Factor (EGF) in a preferably-injectable pharmaceutical composition which is administered by means of infiltration into and around chronic cutaneous ischaemic lesions in order to prevent diabetic foot amputation. Said composition can be administered to recently-created surgical surfaces damaged by the effect of acute reperfusion with oxygenated blood following prolonged ischaemia, thereby preventing further surgical procedures and favoring the preservation of the extremity. The aforementioned composition can be used to improve (i) the cell microenvironment, thereby increasing the reparative and defensive capacity and viability of the is tissues and (ii) the cicatrization of cutaneous ischaemic lesions, thereby stimulating cell proliferation. The invention is suitable for use in human, veterinary and experimental medicine, specifically in vascular angiology and surgery, dermatology, burn treatment and reconstructive surgery and geriatric medicine. Said composition can be used for recalcitrant ulcers which are associated with lesions in the macro and/or microvasculature, patients with inadequate lymphatic and/or venous return and ulcers or other lesions which are difficult to cicatrize and/or heal.

Use of pharmaceutical composition containing epidermal growth factor (EGF) for diabetic foot amputation prevention

Growing community of inventors

Ciudad de la Habana, Cuba

Jose Ignacio Fernandez Montequin