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Universidade Federal De São Paulo - Unifesp

José Eduardo Krieger

Odair Marson

Frida Liane Plavnik

Jeane Mike Tsutsui

Dulce Elena Casarini

Valdemir Melechco Carvalho

Pedro Lemos

Alexandre Da Costa Pereira

Gabriela Venturini Da Silva

Deborah Schechtman

Karina Helena Morais Cardozo

The present invention relates to the identification of a novel biomarker for cardiac ischemia: nitrated cardiac troponin I. The present invention also provides methods for the identification and use of a nitrated cardiac troponin as a biomarker for the diagnosis, prognosis and treatment management of myocardial ischemia, with and without necrosis of heart muscle. Diagnosis and prognosis is conducted by determining the amount of nitrated cardiac troponin I in serum samples of subjects and the ratio of nitrated cardiac troponin I to non-nitrated cardiac troponin I in serum samples of subjects. This biomarker can be detected by immunoassay techniques and tandem mass spectrometry. The present invention further relates to peptides, antibodies, compositions, methods, techniques, tests and kits for the identification and quantification of nitrated cardiac troponin I in samples of subjects.

Nitrated cardiac troponin I as a biomarker of cardiac ischemia

The present invention relates to a method of identification and quantification of proteins, isoforms of angiotensin I converting enzymes (ACE), 190-kDa, specially of 90kDa in tissues, cells and biological fluids, specially in urine, genetic marker and prognostic agent of hypertension and primary or secondary renal lesion and kit for using in the diagnosis, risk stratification and therapeutical decision in arterial hypertension. One the aims of the present invention is to check the potential of the 90 kDa isoform as a hypertension genetic marker isoform and as a prognostic for hypertension.

Method of identification and quantification of proteins, isoforms of the angiotensin I converting enzyme

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São Paulo, Brazil

José Eduardo Krieger