Quantum-si Incorporated

Liminal Sciences, Inc.

Jose Camara

Jonathan Marc Rothberg

Lawrence Camest West

Jason W Sickler

Paul E Glenn

Jonathan C Schultz

Faisal R Ahmad

Keith Glen Fife

Todd Rearick

Jack L Jewell

Jeremy Christopher Jordan

Farshid Ghasemi

John Glenn

Benjamin Cipriany

Brendan Huang

Kamyar Firouzi

Jonathan M Rothberg

Mohammad Moghadamfalahi

Guillaume David

Yichi Zhang

According to some aspects, there is provided a device configured to determine a measure of brain tissue motion in a brain, comprising: at least one transducer configured to transmit an acoustic signal to at least one region of the brain and receive a subsequent acoustic signal from the at least one region of the brain; and at least one processor configured to: determine the measure of brain tissue motion in the at least one region of the brain by processing the subsequent acoustic signal, wherein processing the subsequent acoustic signal comprises filtering the subsequent acoustic signal. Filtering the subsequent acoustic signal may comprise one of spatiotemporal filtering, signal decomposition, tissue tracking, and/or spectral clustering.

Methods and apparatus for pulsatility-mode sensing

Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument. The mode-locked laser can produce sub-50-ps optical pulses at a repetition rates between 200 MHz and 50 MHz, rates suitable for massively parallel data-acquisition. The optical pulses can be used to generate a reference clock signal for synchronizing data-acquisition and signal-processing electronics of the portable instrument.

Compact mode-locked laser module

Compact optical sources and methods for producing short and ultrashort optical pulses are described. A semiconductor laser or LED may be driven with a bipolar waveform to generate optical pulses with FWHM durations as short as approximately 85 ps having suppressed tail emission. The pulsed optical sources may be used for fluorescent lifetime analysis of biological samples and time-of-flight imaging, among other applications.

Optical sources for fluorescent lifetime analysis

Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument for biological or chemical analyses. The pulsed laser may produce sub-100-ps optical pulses at a repetition rate commensurate with electronic data-acquisition rates. The optical pulses may excite samples in reaction chambers of the instrument, and be used to generate a reference clock for operating signal-acquisition and signal-processing electronics of the instrument.

Pulsed laser and bioanalytic system

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Saratoga, CA, United States of America

Jose Camara