New York University

Jose Alejandro Chabalgoity

Thomas M Wisniewski

Einar M Sigurdsson

Blas Frangione

Fernando Goni

Fernando R Goni

Vaccines against prion disease eliciting a humoral immune response when administered mucosally are described. The vaccines comprise a prion protein, a prion protein fragment, or a non-amyloidogenic prion protein homolog and an adjuvant suitable for inducing a humoral immune response after mucosal administration. Suitable adjuvants include cholera toxin subunit B, heat-labile enterotoxin and aluminum hydroxide. Alternatively, the vaccine comprises a vector encoding a prion protein, fragment, or homolog in an attenuatedhost. The vaccines can be used to prevent or treat prion disease in humans and other mammals.

Growing community of inventors

Montevideo Cp, Uruguay

Jose Alejandro Chabalgoity