University of California

California Institute of Technology

Quest Pharmatech, Inc.

Oncoquest Inc.

Jose A Rodriguez

Brian M Stoltz

Birgit Corinna Schultes

Christopher F Nicodemus

Manuel L Penichet

Hosea Nelson

Gustavo Helguera

Tracy R Daniels

Michael Martynowycz

Tamir Gonen

The present disclosure provides methods of collecting electron diffraction patterns from nanocrystals to obtain a three-dimensional structural model of a compound, as well as methods of identifying compounds and methods of determining polymorphic forms. In addition, the present disclosure provides methods of characterizing a first compound from a sample, as well as methods of screening compounds from a sample. The present disclosure also provides systems for characterizing a compound from a sample, which systems include modules for high-performance liquid chromatography, dispensing, and electron microscopy.

Systems and methods for structurally characterizing compounds

The present invention provides monoclonal IgE antibodies comprising Fc epsilon (&#x3b5;) constant regions and variable regions comprising at least one antigen binding region specific for binding a single epitope of a circulating, tumor-associated antigen (TAA) that is not a cell surface antigen wherein the epitope of the targeted antigen is not highly repetitive or is a non-repetitive epitope. The IgE antibodies of the invention are useful in the treatment of cancer associated with the tumor antigen. In one embodiment the TAA is prostate-specific antigen (PSA).

IgE antibodies for the treatment of cancer

Growing community of inventors

Los Angeles, CA, United States of America

Jose A Rodriguez