Ferrer Internacional, S.a.

Ferrer International, S.a.

Jose A Ortiz

Rafael Foguet

Aurelio Sacristan

Josep M Castello

Ernesto Forne

Manuel M Raga

Lluis Anglada

Santiago Gubert

Jordi Bolos

Jose M Castello

Luis Anglada

Rosa M Cuberes

Marcial Moreno

Forms A and B of

Process for preparing

Polymorphs B and C of

5H-thiazolo�3,2-a!pyrimidin-5-one derivatives

4-(6-fluoro-1,2-benzisoxazolyl)-1

N-benzoylmethyl-piperidines

4-p-fluorobenzoyl-1-piperidinyl-propoxy-chromen-4-one derivatives, their

4-Benzylpiperidine derivatives of the formula: ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein X is hydrogen or fluorine and R is hydrogen, or a group selected from p-fluorobenzoyl, .alpha.-hydroxy-p-fluorobenzyl, p-fluorophenoxy, bis(p-fluorophenyl)methyl and 8-azaspiro[4,5]decane-7,9-dione-8-yl-methyl, with the proviso that X and R may not be simultaneously hydrogen and p-fluorobenzoyl respectively. Such compounds are useful as sigma-receptor ligands.

4-benzylpiperidines for treating phychosis

The 1H-imidazole derivative compound of formula I: ##STR1## and its nontoxic addition salts, particularly the nitrate addition salt, are more effective as antimycotic agents and are unexpectedly safer than the corresponding prior art compounds, especially the compound in which the sulfur atom of the benzothiophene ring of the above compound is replaced by an oxygen atom. Pharmaceutical compositions containing an effective amount of the compound of formula I, e.g. 1 to 5% by weight, in a pharmaceutical carrier are safer, more effective, and, in some cases, more reliable with fewer side effects than currently used antimycotic preparations.

1H-imidazole derivative compounds and pharmaceutical compositions

Derivatives of piperazine having the general formula ##STR1## wherein R.sub.1 is benzhydryl or cinnamyl and R.sub.2 is selected from the group consisting of ##STR2## --(CH.sub.2).sub.3 --R.sub.8, --CH.sub.2 NHR.sub.9, --CH.sub.2 NH.sub.2 and --COR.sub.10 ; wherein R.sub.3 is hydrogen, chloromethyl, (4-benzhydryl-1-piperazinyl) methyl, 4-morpholinylmethyl or 1-piperidinylmethyl, R.sub.4 is hydrogen, chloromethyl or carbethoxy, R.sub.5 and R.sub.6 taken together are an oxygen atom or the radical --O--(CH.sub.2).sub.2 --O--, R.sub.7 is methyl, phenyl or 2-thienyl, R.sub.8 is 4-morpholinyl, 1-piperidinyl or 4-benzhydryl-1-piperazinyl, R.sub.9 is 2-oxo-1- (pyrrolidinyl) acetyl, 2-hydroxybenzoyl or 4-sulfamoylbenzoyl, R.sub.10 is 2-oxo-1-(pyrrolidinyl)methyl or 4-sulfamoylphenyl and X is oxygen or NH; as well as methods for making the same and their use in a pharmaceutical composition is proposed. The compounds have cardiovascular properties and increasing effects on cerebral flow.

Derivatives of piperazine, method for making the same

An 1-[2-(phenylmethyl)phenyl]piperazine of the formula (I), ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein R.sub.1 is hydrogen, C.sub.1-4 alkyl or halogen, R.sub.2 is hydrogen, C.sub.1-4 alkyl, halogen or C.sub.1-4 alkoxy and R.sub.3 is hydrogen or methyl. such compounds are useful as antidepressive agents.

1-[2-(phenylmethyl) phenyl]piperazines as antidepressants

A process is disclosed for preparing a 2,3-dihydro-1H-imidazolylethoxy indene antithrombotic agent and its pharmaceutically acceptable salts.

Process for preparing a 2,3-dihydro-1H-imidazolyl-ethoxy indene

2-amino-benzoic acid derivatives, method for making the same as well as its use for therapeutical purposes are proposed. The general formula of 2-amino-benzoic acid derivatives is ##STR1## wherein R represents chlorine or trifluoromethyl,

2-pyrrolidinylethyl-2-(7-trifluoromethyl-4-quinolyl-aminobenzoate having

Sulfonamidine is disclosed of the general formula (I):

Sulfonamidines, process for the production thereof and pharmaceutical

The invention is concerned with the novel thiophene ring-substituted .alpha.-(alkylaminopropionyl)-thiophenes represented by the formula (I), ##STR1## or a pharmaceutically-acceptable salt thereof, a process for the preparation of them, and a pharmaceutical composition which contains these new compounds as active ingredient and can be used as antidepressant agents.

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Barcelona, Spain

Jose A Ortiz