Nordisk Insulinlaboratorium

Jorgen V Jensen

Mirella Ezban Rasmussen

Jorgen F Hansen

An antihemophilic factor preparation (AHF) of high solubility and long half-life is produced in high yields by complete or partial thawing of deep-frozen human blood plasma by irradiation with electromagnetic waves of a frequency of about 10.sup.8 -10.sup.15 for a period of time and with an energy penetration such that the temperature in the thawed plasma does not exceed 10.degree. C. at any point, and processing in a manner known per se by centrifuging the thawed product to form a cryoprecipitate, redissolving the cryoprecipitate in a buffer and isolating a concentrated solution which, if desired, is freeze-dried. Irradiation is preferably effected by microwaves of a frequency of 10.sup.8 -3.times.10.sup.11 Hz, in particular 2.times.10.sup.9 -3.times.10.sup.10 Hz, or by infrared light, said frozen plasma being preheated if desired. The preparation is suitable for injection performed by the patient himself without medical assistance.

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Jorgen V Jensen