Other

Santaris Pharma A/s

Le, Dang Quang Svend

Chen, Muwan

Besenbacher, Flemming

Bünger, Cody Eric

Jorgen Kjems

Jesper Wengel

Henrik Chresten Pedersen

Flemming Besenbacher

Cody Eric Bünger

Mette Katrine Lund

Morten Ostergaard Andersen

Dang Quang Svend Le

Swen Hölder

Menglin Chen

Anette Overgaard Baatrup

Helle Lysdahl

Muwan Chen

The present invention is directed to pharmaceutical and therapeutic compositions which comprise RNA complexes comprising an antisense strand and a discontinued passenger strand capable of regulating gene expression. The use of a discontinued passenger strand reduces off target effects of the RNA complexes and also has other advantages.

Small internally segmented interfering RNA

A method for in vitro selection, from a library of catalyst molecules, of a catalyst molecule of interest having a relatively more efficient specific catalytic activity of interest, as compared to the rest of the catalyst molecules within said library, and wherein said in vitro selection method is characterized by that it allows multiple catalytic activity turn-overs (i.e. substrate to product catalytic activity turn-overs), by the catalyst molecule of interest, before it is finally collected. The method is based on using one or more reagent(s) which are capable of converting a product generated by a catalyst molecule of interest back into the substrate for said catalyst of interest.

Enzyme activity screen with direct substrate reloading

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Risskov, Denmark

Jorgen Kjems