Nordisk Insulinlaboratorium

Jorgen F Hansen

Mirella Ezban Rasmussen

Jorgen V Jensen

An antihemophilic factor preparation (AHF) of high solubility and long half-life is produced in high yields by complete or partial thawing of deep-frozen human blood plasma by irradiation with electromagnetic waves of a frequency of about 10.sup.8 -10.sup.15 for a period of time and with an energy penetration such that the temperature in the thawed plasma does not exceed 10.degree. C. at any point, and processing in a manner known per se by centrifuging the thawed product to form a cryoprecipitate, redissolving the cryoprecipitate in a buffer and isolating a concentrated solution which, if desired, is freeze-dried. Irradiation is preferably effected by microwaves of a frequency of 10.sup.8 -3.times.10.sup.11 Hz, in particular 2.times.10.sup.9 -3.times.10.sup.10 Hz, or by infrared light, said frozen plasma being preheated if desired. The preparation is suitable for injection performed by the patient himself without medical assistance.

Process for producing an antihemophilic factor preparation from human

A process is disclosed for the recovery of albumin in very high purity from human blood plasma by treatment of the blood plasma with polyethylene glycol (PEG) to precipitate out impurities followed by thermocoagulation of a resulting supernatant aqueous solution containing PEG and albumin in the presence of caprylic acid and isolation of the purified albumin by precipitation.

Process for recovering purified albumin from blood plasma using PEG and

Immunoglobulins or gammaglobulins are recovered in a pure and anticomplementary condition by fractionated precipitation of blood plasma with a polycondensed di or polyol, such as PEG, in the presence of a mono or polyalkanoic acid having 4 to 12 carbon atoms, such as caprylic acid.

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Rodovre, Denmark

Jorgen F Hansen