Ferrer Internacional, S.a.

Jorge Ramentol

Rafael Foguet

Manuel M Raga

Josep M Castello

José A Ortiz

Rafael Lozano

Juan Sallares

Inés Petschen

Isidro J Ferrer

Diego Fernandez-Cano

Miguel P Armengol

Francesc X Camps

Julio J Secades

Antonio Guglietta

Lluis Anglada

Esther Gordo

Julián Agut

Jesús Torres

Celia Palacin

Mireia Pasto

The invention describes a prophylactic treatment of cerebral ischemia with CDP-Choline in patients who have undergone major surgery or are at risk of suffering an acute ischemic event.

Use of CDP-choline for the prophylactic treatment of cerebral ischemia

The invention relates to R-(&#x2212;)-1-[2-(7-Chloro-benzo[b]thiophen-3-yl-methoxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole and the salts thereof. The invention also relates to compositions thereof and their use either for treating fungal infections in humans and animals or combating crop diseases. A process for their preparation is also described.

R-(-)-1-[2-(7-chlorobenzo[b]thiopen-3-yl-methoxy)-2-(2,4-dichlorophenyl)-ethyl]-1H-imidazole

The process consists in condensing (2-methyl-6,7,8,9-tetrahydro-4 H-pyrido-[1,2-a]pyrimidin-3-yl)-acetaldehyd with 6-fluoro-3-piperidinyl)-1,2-benzisoxazole to yield the intermediate enamine, 3-{2-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]vinyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2,-a]pyrimidin-4 -one followed by reduction of such an enamine.

Process for preparing 3-(2-(4-(6-fluorobenzo(d)isoxazol-3-yl)-piperidin-1-yl)-ethyl)-2-methyl- 6,7,8,9-tetrahydro-4h-pyrido-(1,2-a)pyrimidin-4-one

The invention describes the prophylactic treatment of cerebral ischemia with CDP-Choline in patients who have undergone major surgery or are at risk of suffering an acute ischemic event.

The invention relates to the use of CDP-Choline or its pharmaceutically acceptable salts for the preparation of a medicinal product for the treatment of alcohol withdrawal syndrome at daily doses equivalent to 0.5-2 g of free CDP-Choline.

Use of CDP-choline for the treatment of alcohol withdrawal syndrome

The present invention relates to a process for preparing (&#xb1;)-trans-4-p-fluorophenyl-3-hyroxymethyl-1-methylpiperdine of formula (I). The present invention also relates to novel intermediates of the formula (IX) and (IX') methods for preparing said intermediates and the use of said compounds for preparing Paroxetine and Omiloxetine.

Process for preparing (&#xb1;)trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidine

Growing community of inventors

Barcelona, Spain

Jorge Ramentol