Louisiana State University and Agricultural & Mechanical College

Portland State University

Jorge O Escobedo Cordova

Robert Michael Strongin

Nadia N St Luce

Martha Sibrian-Vazquez

Isiah Manuel Warner

Mark Allen Lowry

Lei Wang

Jialu Wang

Youjun Yang

Mark Lowry

Tendai Mafireyi

Sayo O Fakayode

Weihua Wang

Xiangyang Xu

Claude Joseph Davis

Oleksandr Rusin

Larry Allen Cabell

Ming He

Patrick T Lewis

Seminaphthofluorophore-selenium probes are disclosed. The probes include a seminaphthofluorophore scaffold substituted with at least one diselenide moiety having a formula —Y—C(Q)O—(CH)—Se—Se—(CH)—OR, where Ris hydrogen or C-Calkyl, Q is O or S, Y is O or N(R) where Ris H or alkyl, and m and n independently are integers. The probes may be used to detect presence of a thioredoxin reductase.

Seminaphthofluorophore-selenium probes for thioredoxin reductase

Molecular probes for detecting and imaging pancreatic cancer are disclosed. The probes are modified benzoxanthene fluorophores, which are selectively taken up by pancreatic cancer cells, such as pancreatic ductal adenocarcinoma cells. Embodiments of the disclosed probes are useful for pancreatic cancer detection, therapeutic monitoring, and/or image-guided surgery.

Molecular probes for detection and imaging of pancreatic cancer

Colorimetric and fluorometric methods are disclosed for the rapid, accurate, selective, and inexpensive detection of homocysteine, or of homocysteine and cysteine, or of cysteine. The methods may be employed with materials that are readily available commercially. The novel methods are selective for homocysteine, for cysteine, or for total homocysteine and cysteine, and do not cross-react substantially with chemically-related species such as glutathione. The homocysteine-selective method does not have substantial cross-reactivity to the very closely related species cysteine. The cysteine-selective method does not have substantial cross-reactivity to the very closely related species homocysteine. The methods may be used, for example, in a direct assay of human blood plasma for homocysteine levels.

Colorimetric and fluorometric determination of homocysteine and cysteine

Xanthene compounds are disclosed having fluorescence at multiple wavelengths. Also disclosed are methods for their synthesis and use. Some of the compounds fluoresce at three wavelengths, emitting white light. Uses include the imaging of biological tissues, illumination, and display technologies. Many of the compounds have large Stokes shifts, and are resistant to photobleaching. The fluorescence may be readily distinguished from that of endogenous fluorophores, and from that of most existing, commercially-available fluorescent probes. The compounds are well suited for use in 'multiplexing' techniques. They exhibit clear isosbestic and isoemissive points, and have broad absorption and emission ranges. 

Fluorescent xanthenes and white light fluorophores

Methods are disclosed for the simple, rapid, and selective colorimetric detection of carbohydrates, including fructose, glucose, sialic acid, and oligosaccharides. There is no need for any prior hydrolysis or other chemical modification or of the analytes. Resorcinarenes, xanthene dyes, and related compounds, formally produced by the reaction of 2 equivalents of resorcinol and a suitable electrophilic condensation partner, are used as chromophores or fluorophores for the detection of sugars and other carbohydrates.

Colorimetric and fluorimetric analysis of carbohydrates

Growing community of inventors

Portland, OR, United States of America

Jorge O Escobedo Cordova