Ayerst, Mckenna & Harrison, Inc.

Biomega, Inc.

Jorge Jaramillo

Dominik M Wernic

John DiMaio

Disclosed herein are derivatives of atrial natriuretic peptides wherein the exocyclic N-terminal peptide segment is deleted and the two cysteinyl residues (at positions 105 and 121) of the natural sequence are replaced with a trivalent unit, --NHCH(CO--)--Q--X--Y--CH.sub.2 CH.sub.2 CO-- wherein Q is methylene, ethylene or CR'R' wherein R' and R' each independently is lower alkyl, X is oxy or thio, and Y is methylene or des-Y. The derivatives may be optionally substituted at various positions including positions 106, 107 and 124. The derivatives possess ANF-like activity and are indicated for treating hypertension and for treating pathological conditions resulting from an imbalance of body fluids and electrolytes.

ANE derivatives with novel bridging

Disclosed are methods and compositions for the prevention of painful conditions in an animal subject comprising the use of (+)(4a,13b-trans)-(3-hydroxy,13b-trans)-3-isopropyl-2,3,4,4a,8,9,13b,14-oc tahydro-1H-benzo[6,7]cyclohepta[1,2,3-de]pyrido[2,1-a]isoquinolin-3-ol, or a therapeutically acceptable acid addition salt thereof, alone or in a potentiating amount in combination with a suitable analgesic agent.

Growing community of inventors

Dollard des Ormeaux, Canada

Jorge Jaramillo