Osteoscreen, Inc.

Southwest Research Institute

Osteoscreen Ip, LLC

Jorge Gianny Rossini

I Ross Garrett

Gregory R Mundy

Gloria Gutierrez

Stephen Thomas Wellinghoff

Xingguo Cheng

Nitin Nitin

The present disclosure relates to a method to stimulate endogenous BMP-2 up-regulation in a subject which method comprises administering to a subject an effective amount of an H1 receptor antagonist, whereby endogenous BMP-2 up-regulation is stimulated in said subject. Also provided is a pharmaceutical formulation including an H1 receptor antagonist present in an effective amount to stimulate BMP-2 up-regulation in a subject and a kit.

BMP-2 upregulating compounds for healing bone tissue and screening methods for selecting such compounds

A medical implant for drug delivery comprising an inner layer of polymer material including a drug dispersed therein and an outer layer which may then mediate the release of the drug in a controllable manner. The outer layer may adhere and/or penetrate the underlying layer and offer a protective coating along with improved mechanical strength along with the ability to hydrate and become permeable to water and allow for drug release.

Coating for medical implants

Compounds that inhibit the activity of the proteasome or the production of proteasomal proteins promote hair growth by stimulating the production of hair follicles, and are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.

Inhibitors of proteasomal activity for stimulating hair growth

This inventions relates to compounds that inhibit the activity of the proteasome and both promotes hair growth and stimulates the production of hair follicles. The compounds provided herein are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.

The present invention relates to compounds that inhibit the activity of the proteasome or the production of proteasomal proteins and promote bone formation and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation, in subject where this is desirable.

Inhibitors of proteasomal activity for stimulating bone growth

Compounds that inhibit the activity of NF-&#x3ba;B or inhibit the activity of the proteasome or both promote bone formation and hair growth and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyrdidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation; they also stimulate the production of hair follicles and are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.

The present invention relates to compounds that inhibit the activity of the proteasome or the productions of proteasomal proteins and promote bone formation and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgey, and post-dental implantation, in subject where this is desirable.

The present invention relates to compounds that inhibit the activity of the proteasome or the production of proteasomal proteins and promote the production of hair follicles and are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.

The present invention relates to compounds that inhibit the activity of the proteasome or the production of proteasomal proteins and promote hair growth and the production of hair follicles and are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.

Growing community of inventors

San Antonio, TX, United States of America

Jorge Gianny Rossini