Bayer Aktiengesellschaft

Troponwerke Gmbh & Co Kg

Troponwerke Gmbh & Co.

Jorg Traber

Thomas Glaser

Peter-Rudolf Seidel

Rudolf Schohe

Bodo Junge

George S Allen

Teunis Schuurman

Harald Horstmann

Wolfgang Dompert

Gerhard-Wilhelm Bielenberg

Bernd Richter

Ulrich Benz

Klaus Opitz

Karl-Heinz Boltze

Jean-Marie V De Vry

Siegfried Raddatz

Eugen Etschenberg

Jean-Marie Viktor De Vry

Willem H Gispen

Margaret A Davies

Herbert Busgen

Maria-Luise Weischer

Teunis Schuurmann

Allen, George

Teunis Thurman

A method of treating depression or stroke in a patient suffering therefrom by administering a substituted aminomethylchroman of the formula ##STR1## in which Z--denotes a group of the formula ##STR2## and R.sup.1, E and F can be hydrogen or other radicals, or salts thereof.

Method for treating depression using substituted aminomethyltetralins

For treatment of disorders of the central nervous system, the cardiovascular system or the intestinal tract, the new substituted basic 2-aminotetralins of the formula ##STR1## in which R.sup.1 represents hydrogen or alkyl,

Substituted basic 2-aminotetralin in pharmaceuticals

Novel 1,3-disubstituted pyrrolidines active on the central nervous system of the formula ##STR1## wherein A--denotes phenyl or hetaryl, which is optionally fused with aromatic, saturated or unsaturated cyclic or heterocyclic hydrocarbons, where this radical can optionally be substituted,

1,3-disubstituted pyrrolidines

The invention relates to the use of 1,4-dihydropyridines having calcium antagonistic action, in particular of nimodipine, for the preparation of medicaments for controlling damage to peripheral nerves which is caused by diabetes.

Use of 1,4-dihydropyridines in diabetes

The invention relates to substituted 2-pyrimidinyl-1-piperazine derivatives defined herein by formula (I), processes for their manufacture, compositions containing said substituted 2-pyrimidinyl-1-piperazine derivatives as active materials and the use of said compounds and compositions as agents effecting the central nervous system. Also included in the invention are intermediates of formula (VIII) for making the active formula (I) compounds.

2-pyrimidinyl-1-piperazine derivatives processes for their preparation

For binding 5-HT.sub.1 receptors and thereby treating central nervous system disorders, novel substituted aminomethyltetralins and their heterocyclic analogues of the formula ##STR1##

Substituted aminomethyltetralins and their heterocyclic analogues

A method of treating cerebral apoplexy in a patient in need thereof which comprises administering to said patient an amount effective therefor of a serotonin agonist which has a binding strength of less than 10,000 nmol/l on binding to 5HT.sub.1A receptors.

Medicaments for the treatment of cerebral apoplexy

2-pyrimidinyl-1-piperazine derivatives

For binding 5-HT.sub.1 receptors and thereby treating central nervous system disorders, novel substituted aminomethyltetralins and their heterocyclic analogues of the formula ##STR1## in which Z--denotes a group of the formula ##STR2## R.sup.1, E and F can be hydrogen or other radicals, or salts thereof.

A method of treating cerebral apoplexy in a patient in need thereof which comprises administering to said patient a amount effective therefor of a serotonin agonist which has an binding strength of less than 10,000 nmol/l on binding to 5HT.sub.1A receptors.

New 8-substituted 2-aminotetralins can be prepared from the corresponding aminotetralins or tetralones. They can be used in medicaments.

Growing community of inventors

Lohmar, Germany

Jorg Traber