Charité – Universitätsmedizin Berlin

Jörg Schnorr

Eyk Schellenberger

Ralf Hauptmann

Matthias Taupitz

Bernd Hamm

Jing Xie

Harald Kratz

Monika Ebert

Susanne Wagner

Angela Ariza De Schellenberger

Ines Gemeinhardt

Nicola Stolzenburg

Gesche Genter

Akvile Häckel

Janna Glaser

Monika Eber

Janna GLÄSER

The invention provides novel iron(III) complexes with formulae (1) and (2). Furthermore, corresponding ligands with formulae (L1) and (L2) for the production of iron(III) complexes are disclosed.

Iron(III) complexes having new contrast agent properties, for magnetic resonance imaging

The present invention relates to a phosphate adsorbent on the basis of maghemite or maghemite/magnetite comprising (i) an iron oxide core comprising a crystal structure of inverse spinel iron oxide, (ii) a coating selected from monomeric carbohydrates, in particular monosaccharides or disaccharides, alditols, or mixtures thereof, and/or (iii) a pharmaceutical excipient selected from polymeric carbohydrates, wherein the phosphate adsorbent has the form of nanoparticles with a particle size of the iron oxide core (i) of less than 20 nm. The present invention further relates to a method for the production of a phosphate adsorbent on the basis of maghemite or maghemite/magnetite, to pharmaceutical compositions comprising the phosphate adsorbent, and to medical uses thereof, especially for the prevention and/or treatment of hyperphosphatemia.

Nanoparticulate phosphate adsorbent on the basis of maghemite or maghemite/magnetite, production and uses thereof

Growing community of inventors

Oranienburg, Germany

Jörg Schnorr