Ciba-Geigy Corporation

Novartis Ag

Jorg Frei

Jaroslav Stanek

Giorgio Caravatti

Hans-Georg Capraro

Guido Bold

Peter Traxler

Atso Ilvespaa

Ernst Schweizer

Knut A Jaeggi

Herbert Schroter

Pascal Furet

Marc Lang

Franz Ostermayer

Andre Gagneux

Franz Ostsewrmayer

Erfinders J Stanek

Wolfgang Karl-Diether Brill

Pyrrolopyrimidines and processes for the preparation thereof

Pyrrolopyrimidines and processes for their preparation

Pyrazole derivatives and processes for the preparation thereof

Imidazole derivatives, their preparation and their use as

Piperidinyl-2-alkyl, substituted linear polyamines for the reduction of

Compounds of formula I ##STR1## wherein A, X, Z and R.sub.1 -R.sub.5 are as defined in the description, and their salts have valuable pharmaceutical properties and are effective especially against tumours. They are prepared in a manner known per se.

Hydrazones

Unsaturate amino compounds for use as anticancer and antiprotozoic agent

Ornithine decarboxylase inhibiting cyclic aminooxy compounds

Compounds of formula I ##STR1## wherein A, X, Z and R.sub.1 -R.sub.5 are as defined in the description, and their salts have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner known per se.

Compounds of formula I ##STR1## wherein A, X.sub.1, X.sub.2, X.sub.3, X.sub.4, Y, Z and R.sub.1 to R.sub.6 have the meanings given in the description, have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner known per se.

Arylhydrazones using as SAMDC inhibitors

Compounds of formula I ##STR1## wherein Y, Z, S, S', m, n and R.sub.1 -R.sub.4 are as defined in the description, have valuable pharmaceutical properties and are effective especially against protozoal infections. They are prepared in a manner known per se.

Bipyridyls

The invention relates to compounds of formula I ##STR1## wherein either R.sub.1 is a radical of formula Ia,

Aminooxy piperidines as ornithine decarboxylase inhibitors

Compounds of formula I ##STR1## wherein A, X.sub.1, X.sub.2, X.sub.3, X.sub.4, Y, Z and R.sub.1 to R.sub.6 have the meanings given in the description, have valuable pharmaceutical properties and are effective especially against tumours. They are prepared in a manner known per se.

Arylhydrazones and pharmaceutical compositions thereof

Compounds of formula ##STR1## wherein R.sub.1 is amino or is a radical ##STR2## wherein R.sub.3 is lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, carboxy, lower alkoxycarbonyl, phenyl, phenyl substituted by lower alkyl, halo-lower alkyl, hydroxy-lower alkyl, halogen, hydroxy, lower alkoxy, lower alkanoyloxy and/or by nitro, pyridyl, pyridyl substituted by lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, phosphonooxy-lower alkyl, lower alkanoyl, carboxy, lower alkoxycarbonyl, hydroxy, lower alkoxy, lower alkanoyloxy, nitro and/or by oxido, or quinolyl, R.sub.4 is hydrogen, lower alkyl, hydroxy-lower alkyl or halo-lower alkyl, or R.sub.3 and R.sub.4 together are C.sub.4 -C.sub.6 alkylene or benzo-C.sub.4 -C.sub.6 alkylene, and R.sub.2 is straight-chain C.sub.1 -C.sub.4 alkyl, and salts thereof, have a strong specific inhibitory action on the enzyme ornithine decarboxylase. The compounds of Formula I are prepared according to processes known per se.

Hydroxylamine compounds

Arylhydrazones and pharmaceutical compositions containing the same

Growing community of inventors

Holstein, Switzerland

Jorg Frei