Bayer Aktiengesellschaft

Jorg Baumgarten

Werner Frommer

Imre Pascik

Axel Kretschmer

Dietmar Schapel

Michael Sperzel

Wolfgang Springer

Hans-Georg Rast

Theo Mann

Delf Schmidt

Hans-Georg Lerchen

Burkhard Mielke

Karsten Von Dem Bruch

Udo Stropp

Horst-Peter Antonicek

Antonius Lobberding

Helga Rubsamen-Waigmann

Helmut Brunner

Friedrich Schmidt

Walter Strube

Peter Thein

Heinz Kolbl

Lothar Biesert

Norbert Piel

Douglas M Munnecke

Antonius Loebberding

Mark-Michael Struck

Hary Suhartono

Thomas-Peter Hausner

Inge Flesch

Heinz Hildebrand

Alois Molitor

Claus Muller

Jorg Krauling

Glycoconjugates of modified camptothecin derivatives (A-or B-ring

The invention relates to polynucleotides which contain pseudorabies virus sequences, in particular sequences from the gII region of PRV, in the antisense orientation, their preparation and their use.

Pseudorabies virus (PRV) polynucleotides and their use for preparing

The present invention relates to the targeted blocking of the genetic information of the viral messenger ribonucleic acid (mRNA) for virus replication (e.g. of HIV) in transfected, haematopoietic cells with particularly suitable expression systems, which express a complementary 'antisense RNA'.

HIV antisense expression vectors

An apparatus for cultivating immobilized micro-organisms consisting of a fluidized bed reactor with fittings for gassing and a retainer system for the immobilized biocatalysts. The fluidized bed reactor is characterized in that the fittings for gassing consist of several segments with gas outlets arranged on the base of the fluidized bed reactor, which admit gas alternately or cyclically. A central gas outflow opening, pointing upwards, can be provided in the fluidized bed reactor as a further gassing unit. The method of operating the fluidized bed is characterized in that circulating gassing occurs in the reactor by means of sequential opening of the gas inflow openings of the segment-shaped fittings. In addition, switches may occur from the central gassing unit to gassing by means of the segment-shaped fittings or vice-versa.

Apparatus for the cultivation of immobilized micro-organisms

A process for the preparation of glycoproteins and proteins from cultures of archaebacteria, comprising culturing archaebacteria, isolating glycoprotein and/or protein from the archaebacteria or their cell walls, enzymatically degrading the glycoprotein and/or protein, purifying and isolating the degradation products, and separating those fractions in the individual purification steps based on the biological activity of the fraction. The products increase the body's defenses against infection.

Preparation of immunologically active cell wall components from

Waste water and/or outgoing air are purified by contact with a polyurethane hydrogel containing surface active coal, a polymer having cationic groups and cells having enzymatic activity and being capable of growth.

Biologically active composition for purifying waste water and outgoing

A biologically active composition is prepared comprising a polyurethane hydrogel containing surface active coal, a polymer having cationic groups and cells having enzymatic activity and being capable of growth. The composition is used for purifying waste water and outgoing air.

Immobilization of cells in polyurethane hydrogel

A process for the production of a storage-stable preparation of micro-organisms, starting from a mixed culture of micro-organisms, which is capable to degrade products of industrial organic syntheses, which comprises that the culture conditions of an active mixed culture enriched in the customary manner are optimized, with the addition of the product to be degraded, in the customary manner according to the rate of degradation of the product and this mixed culture is converted in at least two passes into a stabilized activated mixed culture under the optimum conditions thus determined, and the culture thereby obtained is rendered storage-stable, its activity being maintained.

Preparations of micro-organisms

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Wuppertal, Germany

Jorg Baumgarten