Laboratorios Lesvi, S.l.

Jordi Cerón Bertran

Pere Dalmases Barjoan

Juan Huguet Clotet

Glòria Freixas Pascual

Jordi Benet-Buchholz

Jordi Bessa Bellmunt

Lluis Solà Carandell

Pere Dalmases

Isabel Navarro Muñoz

Isabel Navarro MUÑOZ

Lluís Sola Carandell

Antonio Abelino De León Martín

A monoclinic crystalline form of asenapine maleate is described, which is characterized in that it is not micronised and has a particle size distribution characterized by a d90 of 40 &#x3bc;m or less. A process for the preparation of a monoclinic crystalline form of asenapine maleate is also described, the process comprising the following steps: a) providing a mixture of monoclinic asenapine maleate and an organic solvent which, under the conditions of the process, acts as an antisolvent; b) stirring the mixture at a temperature between 15 and 60&#xb0; C.; and c) collecting the crystals, wherein the organic solvent is selected from alcohols, ketones, ethers, esters, hydrocarbons or mixtures thereof.

Monoclinic crystalline form of asenapine maleate with a specific particle size distribution

New polymorphic form of a long-acting beta-2 adrenoceptor agonist A new polymorphic form of arformoterol tartrate, designated as form D, is provided and which is characterized by at least one of the following: (i) a powder X-ray diffraction pattern having peaks at approximately 6.8, 13.3, 13.6, 3.8, 14.1, 18.2, 18.7, 20.0&#xb1;0.2 degrees two theta; or (ii) a DSC thermogram showing an endothermic peak with an onset at approximately 19-120&#xb0; C., and a maximum at approximately 129-131&#xb0; C., followed by an exothermic peak with a maximum at approximately 137-138&#xb0; C.; wherein the DSC thermogram of form D has a further endothermic peak with an onset at approximately 168-170&#xb0; C.1 Processes for preparing the new polymorphic form, uses thereof and intermediates for the preparation thereof, are also provided.

Polymorphic form of a long-acting beta-2 adrenoceptor agonist

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Tarragona, Spain

Jordi Cerón Bertran