Laboratorios Del Dr. Esteve S.a.

Laboratories Del Dr. Esteve S.a.

Laboratorios Lesvi, S.l.

Jordi Carles Ceron Bertran

Lluis Sola Carandell

Helmut Heinrich Buschmann

Jordi Benet Buchholz

Nicolas Tesson

Pere Dalmases Barjoan

Carlos Ramon Plata Salaman

Juan Huguet Clotet

Jordi Bessa Bellmunt

Antonio Abelino De Leon Martin

The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.

Co-crystals of tramadol and NSAIDs

The present invention relates to co-crystals of duloxetine and co-crystal formers selected from COX-INHIBITORS, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.

Co-crystals of duloxetine and cox-inhibitors for the treatment of pain

The present invention refers to an improved method for the preparation of compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid substantially free of its 3H-I isomer. The invention also refers to the use of said intermediate for the preparation of Rufinamide and for obtaining a new polymorphic form of Rufinamide, designed as Form R-5. The invention also refers to said new polymorph of Rufinamide, and to the composition containing it and its use as medicament. The new polymorph of Rufinamide shows good stability and appropriate physico-chemical properties for its manipulation on industrial scale. Polymorph Form R-5 will be suitable to use as pharmaceutical for the treatment of convulsions, especially for the treatment of epilepsy.

Process for preparing rufinamide intermediate

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Tarragona, Spain

Jordi Carles Ceron Bertran