Medichem, S.a.

Jordi Bosch I Llad&oacute;

Maria Del Carmen Onrubia Miguel

Pelayo Camps Garcia

Ma Carmen Onrubia Miguel

Carmen Arnalot I Aguilar

N&uacute;ria Soldevilla Madrid

Eugenia Pagans Lista

Ma Del Carmen Onrubia Miguel

The invention relates to a process for the preparation of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid and of the trihydrated monosodium salt thereof, consisting of reacting 4-aminobutyric acid with a phosphonation mixture formed by phosphorous acid and methanesulfonic anhydride and thereafter hydrolyzing the product of said reaction and isolating the products by adjustment of the pH.

Process for producing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid and its trihydrated monosodium salt

The invention discloses a process for the preparation of the polymorh A of doxazosin meylate, consisting essentially of reacting doxazosin base with methanesulfonic acid in a mixture of solvents containing an alcohol and a chlorinated solvent, subsequently removing the chlorinated solvent by distillation and precipitating the desired product in an alcohol, after heating the suspension formed to the reflux temperature of the solvent.

Method for obtaining polymorph a from doxazosine mesylate

A process for the preparation of venlafaxin and/or the physiologically acceptable addition salts thereof that consists of reacting a compound of general formula (II) where R is a C -C alkyl, aryl, aralkyl or cycloalkyl group of 3 to 6 atoms of carbon, with a organomagnesium compound of general formula (III) where X is an atom of halogen and, if desired, a salt of the thus obtained venlafaxin is formed by reaction thereof with a physiologically acceptable acid.

Venlafaxine production process

Growing community of inventors

Girona, Spain

Jordi Bosch I Lladó

Growing community of inventors

Girona, Spain

Jordi Bosch I Llad&oacute;

Jordi Bosch I Lladó