The University of Tennessee Research Foundation

Jordan J Toutounchian

Duane Douglas Miller

Charles Ryan Yates

Jena Steinle Smith

Jayaprakash Pagadala

Karin Emmons Thompson

Shivaputra Appanna Patil

Kui Zeng

Frank Park

Mostafa Waleed Gaber

Vanessa Morales-Tirado

Bilal Abou Aleiwi

Vanessa M Morales-Tirado

Shivaputra Patil

Here provided is a method for regulating retinal endothelial cell viability in a mammal by administering to the mammal a therapeutically effective amount of a quinic acid analog. The method may be applied to prevent, treat or cure pathological conditions of retinal endothelial cells associated with radiation retinopathy, diabetic retinopathy and chemotherapy for retinoblastoma.

Method for regulating retinal endothelial cell viability

This disclosure relates to small molecule inhibitors of paxillin and paxillin binding, and related compositions and methods of treatment.

Inhibitors of paxillin function and related compositions and methods

Disclosed are methods of use of analogs of quinic acids or shikimic acids for protection from the harmful effects of radiation when administered either prior to radiation exposure, after radiation exposure, or both. These methods are useful for treating humans and animals exposed to radiation and at risk for radiation sickness and/or death as the result of radiation exposure.

Anti-inflammatory quinic acid derivatives for radioprotection/radiomitigation

Growing community of inventors

Memphis, TN, United States of America

Jordan J Toutounchian