Sunovion Pharmaceuticals Inc.

Jordan Dubow

Scott David Barnhart

Anthony John Giovinazzo

Michael Clinton Koons

Madhu Hariharan

Thierry Bilbault

Madhu Sudan Hariharan

Methods and pharmaceutical unit dosage forms for treating Parkinson's disease in a subject (e.g., an 'off' episode in a subject having Parkinson's disease) are described. The pharmaceutical unit dosage forms are films having a first portion including particles containing an acid addition salt of apomorphine and a second portion containing a pH neutralizing agent. The pharmaceutical unit dosage forms can be flexible and have toughness greater than 100 g&#xd7;mm. The methods can involve administering to a subject having Parkinson's disease a therapeutic dose sufficient to produce an apomorphine plasma concentrate of at least 2.64 ng/mL within 45 minutes after the administration. The subject may be identified as having low uptake, medium uptake, or high uptake of apomorphine administered via oral mucosa.

Methods of treating Parkinson's disease by administration of apomorphine to an oral mucosa

Methods of treating parkinson's disease by administration of apomorphine to an oral mucosa

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Glencoe, IL, United States of America

Jordan Dubow