Mayo Foundation for Medical Education and Research

Gentex Corporation

Other

Jordan D Miller

Bin Zhang

William L Tonar

Bradley R Hamlin

Kurtis L Geerlings

Jason D Hallack

David M Falb

Joshua D Lintz

Steven J Veenman

Jeremy A Schut

Mark A VanVuuren

Heidi Nelson

James L Kirkland

Tamar Tchkonia

Yi Zhu

Travis Miller

Allyson K Palmer

Nathan K LeBrasseur

Maurice E Enriquez-Sarano

Carolyn Marie Roos

Michael F Romero

Kianoush B Kashani

Adam J Rossano

This document provides methods and materials involved in treating cardiovascular conditions such as calcific aortic valve stenosis. For example, methods and materials for using sGC agonists or a combination of sGC agonists and PDE5A inhibitors to reduce calcification of heart valves and/or vessels or to slow progression of aortic sclerosis to calcific aortic valve stenosis are provided.

Methods and materials for gender-dependent treatment of cardiovascular dysfunction

An illumination system for a lighting assembly comprises a light assembly configured to selectively illuminate an operating region in a surgical suite and a plurality of light sources positioned within the light assembly and configured to emit light. The system further comprises at least one imager configured to capture image data and a controller. The controller is configured to scan the image data in at least one region of interest for a shaded region and identify a location of the shaded region within the region of interest. The controller is further configured to control the light assembly to activate at least one of the light sources to emit light impinging on the shaded region within the region of interest.

Systems and methods for detection and illumination of regions of interest

Provided herein are methods and uses for treatment or prophylaxis of a senescent cell associated disease or disorder by administering a senolytic combination comprising dasatinib and quercetin or an analog thereof to a subject in need thereof. In certain embodiments, the senescent cell associated disease or disorder is a cardiovascular disease or disorder, inflanunatory disease or disorder, a pulmonary disease or disorder, a neurological disease or disorder, or a metabolic disease or disorder.

Killing senescent cells and treating senescence-associated conditions using a SRC inhibitor and a flavonoid

A disposable stoma plug includes an absorbent body and a grip device. The absorbent body has a bottom end and a top. The bottom end is configured for insertion into a stoma opening. The grip device is connected to the top of the absorbent body. The grip device is configured for handling the absorbent body for inserting and removing the absorbent body into and from the stoma opening. Wherein, the stoma plug is configured to briefly seal off the stoma opening of an urostomy, an ileostomy, or a colostomy to prevent bodily fluids from leaking from the stoma opening, thereby, keeping surrounding skin free and dry while changing dressings, bandages or a collection bag.

Disposable stoma plug and method of use thereof

Methods and materials for treating calcific aortic valve stenosis

A light assembly is configured to selectively illuminate an operating region in a surgical suite. The assembly comprises a plurality of lighting modules comprising a plurality of light sources configured to emit light. The assembly further comprises at least one imager configured to capture image data disposed in at least one of the lighting modules. An articulating head assembly is configured to support each of the lighting modules. The articulating head assembly comprises a plurality of actuators configured to rotate each of the lighting modules about a first axis and a second axis. The assembly further comprises a controller. The controller is configured to scan the image data for at least one region of interest comprising at least one of a shaded region and a contaminated region.

Adaptive lighting array with image-based control

An audio amplified combustion system is described that has a fuel injector a positioned proximate to a speaker so that a flame moves in concert with audio emitted from the speaker. A projection column and projection top can be positioned above the cone of the speaker to define a volume for the combustion. Various apparatuses, methods, and systems for keeping the speaker cool are also described. Coating on various parts of the system to increase or decrease emissivity or absorptivity of various parts can keep the speaker cool. In addition, a control unit can cause the speaker to 'pant' or vibrate at a low or high frequency to induce convective and keep the speaker cool. These and other features of the audio amplified combustion system are described herein.

Apparatus, system, and method for audio amplified combustion

Materials and methods for using DNA methyltransferase inhibitors to slow progression of aortic valve calcification and stenosis are provided.

Using DNA methyltransferase inhibitors to treat calcific aorta valve disease

Growing community of inventors

Rochester, MN, United States of America

Jordan D Miller