Teknologian Tutkimuskeskus Vtt Oy

Joosu Kuivanen

Peter Richard

Dominik Mojzita

Anssi Rantasalo

Merja Penttilä

Outi Koivistoinen

Ying-Mong Jasmin Wang

Christopher Landowski

Heiko Rischer

Kirsi-Marja Oksman-caldentey

Jussi Jäntti

Jussi Jantti

Merja PenttilÄ

A recombinant host cell is disclosed for producing psilocybin and related compounds, such as metabolic intermediates of the psilocybin biosynthesis. Also provided is a method of producing psilocybin and its synthesis intermediates and related compounds, such as metabolic intermediates of the psilocybin biosynthesis, in the host cell, as well as a production system for producing them.

Heterologous production of psilocybin

The present invention provides an expression system for a eukaryotic host, which comprises 1) an expression cassette comprising a core promoter, the core promoter controlling the expression of a DNA sequence encoding a synthetic transcription factor (sTF), and 2) one or more expression cassettes each comprising a DNA sequence encoding a desired product operably linked to a synthetic promoter, the synthetic promoter comprising a core promoter, and sTF-specific binding sites upstream of the core promoter. The present invention also provides a method for identifying universal core promoters for eukaryotic hosts, expression systems using universal core promoters, hosts comprising the systems, and methods for producing protein products in eukaryotic hosts.

Expression system for eukaryotic organisms

The present invention relates to a field of genetically modified fungal cells and converting galacturonic acid to meso-galactaric acid, more precisely to a method of producing meso-galactaric acid. The invention further relates to recombinant fungal cells having a specific combination of modifications including but not limited to expression of uronate dehydrogenase enzyme, reduced D-galacturonic acid reductase activity, and furthermore reduced meso-galactaric acid catabolism, as well as uses and methods related thereto.

Method for producing meso-galactaric acid by contacting a fungal cell with a biomaterial having galacturonic acid

The present invention concerns a eukaryotic host selected from microorganisms, and a method for producing glycolic acid using said eukaryotic host cells, especially cells of a genetically modified fungal host. Further this invention relates to a glycolic acid product obtained using the method described here and the use of genetically modified microorganism cells in production of glycolic acid.

Eukaryotic cell and method for producing glycolic acid

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Espoo, Finland

Joosu Kuivanen