Cilag International Gmbh

Ethicon, Gmbh

Gatt Technologies Bv

Cilag Gmbh

Joost Opsteen

Gerard H Llanos

Johannes Caspar Mathias Elizabeth Bender

Rosa Pilar Félix Lanao

Abraham Reinier Keereweer

Sander Cornelis Gerardus Leeuwenburgh

María José Sánchez-fernández

Jan Cornelis Maria Van Hest

María José SÁNCHEZ-FERNÁNDEZ

Rosa Pilar FÉLIX Lanao

Biocompatible, flexible, haemostatic sheets are provided comprising a water-resistant cohesive fibrous carrier structure comprising a three-dimensional interconnected interstitial space and fibres comprising a nucleophilic polymer carrying reactive nucleophilic groups; and distributed within the interstitial space throughout the fibrous carrier structure, a plurality of reactive polymer particles comprising a water-soluble electrophilic polymer carrying at least three reactive electrophilic groups that are capable of reacting with both amine groups in tissue and blood and with the reactive nucleophilic groups of the nucleophilic polymer to form covalent bonds, wherein the reactive polymer particles have a diameter between 0.5-100 μm and are present in an amount of at least 3% by weight of the fibrous carrier structure.

Biocompatible, flexible, haemostatic sheet

The present disclosure provides polyoxazoline (POx) copolymers which exhibit very high affinity for calcium ions, are capable of forming hydrogels and are bioresorbable. The polyoxazoline copolymers comprise at least 20 oxazoline units, including at least 4 non-terminal oxazoline units that contain a calcium binding group. Methods of making such polyoxazoline copolymers and using them in biomedical applications are also provided.

Polyoxazoline copolymer comprising calcium binding groups

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Joost Opsteen