Ecole Polytechnique Federale De Lausanne

Bruker Biospin Ag

Bruker Biospin Gmbh

University of York

Ecole Polytechnique Féderale De Lausanne (Epfl)

Joost Lohman

Geoffrey Bodenhausen

Sami Jannin

Antonio Giuseppe Gianotti

Frank Engelke

Simon Benedict Duckett

Aurélien Bornet

Gary George Green

Roberto Melzi

Klaes Golman

A method for producing hyperpolarized sample material for use in magnetic resonance investigations involves preparing a target material containing high &#x3b3; nuclei with a short T, a polarizing agent with a broad EPR line, and low &#x3b3; nuclei with a long T. The polarizing agent in the target material is irradiated with microwave radiation, wherein the target material is at a cryogenic temperature and exposed to a static magnetic field B&#x2267;4.0 T, thus polarizing the high &#x3b3; nuclei by DNP, and the polarization is transferred from the high &#x3b3; nuclei to the low &#x3b3; nuclei by Cross Polarization. A dissolved sample material is prepared containing the hyperpolarized low &#x3b3; nuclei from the target material. Nuclei with a long longitudinal relaxation time Tcan thereby be quickly hyperpolarized to a high polarization level.

MRI compatible method and device for rapid DNP on a solid state hyperpolarized sample material

A method for producing a hyperpolarized sample for use in a magnetic resonance investigation has the following steps: a) providing a solid sample (), containing long Tnuclei and short Tnuclei in the same molecules (); b) hyperpolarizing the short Tnuclei in the solid sample (); c) transforming the solid sample () into a liquid sample (); and d) transferring the polarization of the short Tnuclei to the long Tnuclei within the molecules in the liquid sample () by Cross Polarization. The method can provide samples with hyperpolarized long Tnuclei, in particularC orN, in a simple and efficient way.

Method for hyperpolarization transfer in the liquid state

An NMR experiment on hyperpolarizable magnetic nuclei of substrate molecules in a living human or animal body, involves polarizing the substrate molecules by non-hydrogenating para-hydrogen induced polarization (=NH-PHIP) into a singlet/pseudo singlet state in low magnetic field and injecting the substrate molecules into the living body, the body or a part thereof being previously located inside a magnet at low magnetic field. The magnet is switched on to high magnetic field, and in at least part of the substrate molecules, the singlet state/pseudo singlet state is converted into observable magnetization. An MRI or MRS measurement is carried out with the living body or the part thereof, collecting data from the substrate molecules. The NMR experiment is well applicable on hyperpolarized nuclei within a patient, with reduced losses of magnetization due to relaxation processes.

Field cycling method for magnetic resonance

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Kenilworth, United Kingdom

Joost Lohman