Koninklijke Philips Corporation N.V.

Nederlandse Organisatie Voor Toegepast-natuurwetenschappelijk Onderzoek Tno

Siemens Healthineers Nederland B.v.

Joost Hubert Maas

Albert Hendrik Jan Immink

Menno Willem Jose Prins

Emiel Peeters

Toon Hendrik Evers

Dominique Maria Bruls

Marius Iosif Boamfa

Wendy Uyen Dittmer

Sima Asvadi

Godefridus Johannes Verhoeckx

Thea Van Der Wijk

Menno W J Prins

Bernardus Jozef Maria Beerling

Remco Den Dulk

Marlieke Joan Overdijk

Monica Scholten

Dirkjan Bernhard Van Dam

Maatje Koets

Ralf Guillaume Jean Catharina Heijkants

Joukje Garrelina Orsel

Mara Johanna Jacoba Sijbers

Albert H J Immink

Nicole Henrica Maria Smulders

Aafke Tessa Ten Cate

Michel J M Bruyninckx

An apparatus and method for predicting a fertility window include an image capture device and a processor. The fertility window includes a period of increased fecundability for a woman based on optical monitoring of facial features. The image capture device is configured to record images including facial features of a subject. The processor is configured to receive data corresponding to the recorded plural images; determine from the data changes in the facial features; and predict a fertility window based on the determination.

Apparatus, method and medium for predicting and displaying a fertility window of a woman

The invention relates to a cartridge () for processing of a liquid sample, for example for the detection of components in a sample of blood. The cartridge comprises a fluidic system with an intake port () leading via an intake capillary channel () to a storage chamber (). Moreover, a feeding capillary channel () leads from the storage chamber () to a detection chamber (). The design of the cartridge () is such that the intake capillary channel () that connects the intake port () to the storage chamber (), has a capillary suction pressure sufficiently high to drive some sample from the intake port to the storage chamber without need of any additional pressure. Furthermore the cartridge a flow control element () adapted to be externally controllable such that the sample can be drawn from the storage chamber () towards the processing chamber () without any active pumping.

Cartridge for fast sample intake

The present invention discloses microfluidic devices with a valve-like structure (3), through which magnetic particles can be transported with minimal transport of fluids. This allows sequential processing of the magnetic particles.

Multi-compartment device with magnetic particles

A cartridge () and a method process target components (T, T) of a sample fluid, for example the detection of cardiac markers in blood. The cartridge () includes a reaction chamber () with a hydrophilic reaction surface (). A physical barrier () on the reaction surface (), for example a protrusion, at least partially borders an investigation region (') which includes capture probes (CP, CP) that specifically bind to target components (T, T) of the sample fluid.

Processing of a sample fluid with target components

The present invention relates to 'grafting to' methods of modifying materials surfaces with high-density polymer brushes. A method of the present invention comprises contacting in succession or simultaneously an activated material surface, a solution of a polymeric material having a polymeric backbone with pendant reactive moieties, and a melt of brush-forming terminally-functionalized polymer chains, in order to allow a covalent bonding reaction to occur between surface and polymers, wherein upon completion of the reaction, the polymeric material forms a layer between the material surface and the brush polymer chains.

Method of modifying materials surfaces

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Eindhoven, Netherlands

Joost Hubert Maas