Samsung Electronics Co., Ltd.

Il Dong Pharmaceutical Co., Ltd.

Joontae Park

Sangchul Park

Kobong Choi

Hyuntae Kang

Chulwon Jung

Hyojei Choi

Jung Woo Lee

Gunhee Kim

Jin Hee Lee

Kyung Mi An

Changmok Oh

Te-ik Sohn

Yearin Jun

Jungwon Keum

Youngsam Lee

Seolhee Lee

Jooyun Lee

Dami Lim

Jinsun Kwon

Ilji Jeong

Kyeong-A Kim

Jungho Kim

Jaeeun Ryu

Hongchul Yoon

Jongmin Yoon

Myongjae Lee

The present disclosure provides CFTR modulator and phosphodiesterase 4 (PDE4) inhibitor compounds of the formula (Ia): and compositions including said compounds. The compounds can provide functionality for modulating CFTR, methods for treating an eye disease or disorder, and methods for treating CFTR-related indications. The present disclosure also provides methods of using said compounds and compositions for inhibiting PDE4 in a biological system or biological sample, for treating an inflammatory disease or disorder, and for treating other PDE4-related indications. Also provided are methods of preparing said compounds and compositions, and synthetic precursors of said compounds.

Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators

A composition for reducing a level of senescence of a cell or subject, a method of reducing a level of senescence in a cell or subject by using the composition, and a method of preventing and treating symptoms or diseases related to or caused by senescence of a cell or subject.

Composition for reducing senescence of cell or subject comprising smurf2 inhibitor and use thereof

A composition for reducing cell senescence including a Rho-kinase inhibitor and method of treating a cell senescence-related symptom in mammals.

Composition for reducing cell senescence comprising Rho-kinase inhibitor and use thereof

A composition including an ataxia telangiectasia mutated (ATM) inhibitor for reducing cellular senescence, a method of reducing cellular senescence in a mammal, and a method of treating a symptom associated with cellular senescence in a mammal.

Composition including ATM inhibitor for reducing cellular senescence and use of the composition

Provided is a method of reducing senescence in a cell or subject, or treating or preventing a symptom or disease associated therewith, by administering a BRAF inhibitor to the cell or subject.

Composition for reducing senescence of cell or subject including BRAF inhibitor and use thereof

Growing community of inventors

Seoul, South Korea

Joontae Park