Alcon Laboratories, Inc.

Alcon Manufacturing, Ltd.

Alcon, Inc.

Joonsup Park

Joseph J Falcetta

Nissanke L Dassanayake

Ronald L Schlitzer

Nathaniel D McQueen

Bahram Asgharian

Bor-Shyue Hong

Ronald P Quintana

Evan P Kyba

Christina G Smith

Biguanide/quaternary ammonium compounds and the use of same as antimicrobial agents in pharmaceutical compositions are described. The biguanide/quaternary ammonium compounds are useful in the preservation of pharmaceutical compositions, particularly ophthalmic pharmaceutical compositions and compositions for treating contact lenses. The compounds are especially useful for disinfecting contact lenses.

Biguanide/quaternary ammonium containing copolymeric biocides and use thereof in pharmaceutical compositions

Aminobiguanides and the use of same as antimicrobial agents in pharmaceutical compositions are disclosed. The aminobiguanides are useful in the preservation of pharmaceutical compositions, particularly ophthalmic pharmaceutical compositions and compositions for treating contact lenses. The compounds are especially useful for disinfecting contact lenses.

Aminobiguanides and the use thereof to disinfect contact lenses and preserve pharmaceutical compositions

Amido polybiguanides and their use as antimicrobial agents in pharmaceutical compositions are disclosed. A method of synthesis of amido polybiguanides is also disclosed. The amido polybiguanides are useful in the preservation of pharmaceutical compositions, particulary opthalmic and otic pharmaceutical compositions and compositions for treating contact lenses. The compounds are especially useful for disinfecting contact lenses.

Amido polybiguanides and the use thereof as antimicrobial agents

Bis-amido polybiguanides and their use as antimicrobial agents in pharmaceutical compositions are disclosed. A method of synthesis of bis-amido polybiguanides is also disclosed. The bis-amido polybiguanides are useful in the preservation of pharmaceutical compositions, particularly ophthalmic and otic pharmaceutical compositions and compositions for treating contact lenses. The compounds are especially useful for disinfecting/cleaning contact lenses.

Bis-amido polybiguanides and the use thereof to disinfect contact lenses and preserve pharmaceutical compositions

Polymeric quaternary ammonium compounds and their use as ophthalmic

N,N-dialkyl and N'-alkylethylene diamines of the formula: ##STR1## wherein R, R.sup.1 and R.sup.2 are as described in the specification. The compounds are useful in disinfecting and cleaning contact lenses and preserving ophthalmic products.

Use of diamines to disinfect and clean contact lenses and preserve

The invention discloses PEG-modified proteases, compositions containing these modified enzymes, and methods for using them to clean contact lenses. The methods of the present invention are also directed to the simultaneous cleaning and disinfecting of contact lenses, when compositions of the present invention are combined with a suitable disinfectant.

Peg-modified proteases and methods of use in contact lens cleaning

Use of amidoamines in ophthalmic compositions

The use of certain amidoamines to disinfect contact lenses and preserve ophthalmic compositions is described, Ophthalmic compositions containing these compounds as disinfecting agents or preservatives are also described, The amidoamines utilized in the present invention have potent antibacterial and antifungal activity, and are chemically compatible with inorganic ions and other materials utilized in ophthalmic compositions.

PEO-containing quaternary ammonium compounds have good broad spectrum antimicrobial activity. These compounds are useful in pharmaceutical compositions as preservatives and in contact lens care compositions as preservatives and/or disinfectants.

Polyethylene oxide-containing quaternary ammunium polymers and

Novel quaternary ammonium siloxane compounds and methods for their use are disclosed.

Quaternary ammonium siloxane compounds and methods for their use

Certain amidoamines, the use of same for disinfecting and cleaning contact lenses and preserving ophthalmic products, and associated ophthalmic compositions are described.

Novel polymeric antimicrobials having spacer moieties between amine and/or ammonium moieties have good antifungal activity. These compounds are useful in pharmaceutical and cosmetic compositions as preservatives and in contact lens care compositions as preservatives and/or disinfectants.

Polymeric antimicrobials and their use in pharmaceutical compositions

Two compounds, which are derivatives of 2(2-hydroxyphenyl) 2H-benzotriazole, are copolymerized with hydrogel forming monomers to form ultraviolet absorbing hydrogels. These hydrogels have many potential applications. For instance, they can be used to make contact lenses and intraocular lenses which are particularly useful for aphakics.

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Arlington, TX, United States of America

Joonsup Park