Korea Research Institute of Bioscience and Biotechnology

Joonsung Hwang

Bo Yeon Kim

Jong Seog Ahn

Jae-Hyuk Jang

Nak Kyun Soung

In Ja Ryoo

Hee Gu Lee

Kyung Ho Lee

Hyunjoo Cha

Sun Ok Kim

Krisada Sakchaisri

Mija Ahn

Jiyun Mun

Srinivasrao Ganipisetti

Ramegowda Thimmegowda Naraganahalli

Sung-Kyun Ko

The present invention relates to a composition for preventing, alleviating or treating inflammatory diseases, comprising, as an active ingredient, an acylhydrazone derivative compound, a stereoisomer thereof or a pharmaceutically acceptable salt thereof. an acylhydrazone derivative compound, a stereoisomer thereof or a pharmaceutically acceptable salt thereof, of the present invention, effectively inhibits inflammatory cytokines and inflammatory signaling pathways, thereby effectively alleviating symptoms of inflammatory diseases such as dermatitis. Therefore, the composition according to the present invention may be effectively used for the prevention, alleviation or treatment of inflammatory diseases.

Anti-inflammatory composition comprising acylhydrazone derivative

The present invention relates to ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate, the novel mitosis inhibitor. The said ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate not only induces apoptosis by inhibiting tubulin polymerization in the course of mitosis but also displays an excellent anticancer effect in the multi-drug resistant cancer cells, so that it can be effectively used for the treatment of cell proliferative disease including various cancers.

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Daejeon, South Korea

Joonsung Hwang