Korea Research Institute of Bioscience and Biotechnology

Korea Institute of Oriental Medicine

Korea Institute of Bioscience and Biotechnology

Joongku Lee

Byoung-Mog Kwon

Dong Cho Han

Yoon-Jeong Jeon

Soo Hyun Kim

Kyung Seop Ahn

Sei Ryang Oh

Sang Ho Choi

Sang Woo Lee

Hyeong Kyu Lee

Ok-Kyoung Kwon

Sei-Ryang Oh

Doo-Young Kim

Jung Weon Lee

Hyouk Joung

Sangku Lee

Jung-hee Kim

Wan Yi Li

Hang Jin

Mee-Young Lee

Hwa-Young Son

Kyoung-youl Lee

Hyeong-Kyu Lee

Sangho Choi

Kyungseop Ahn

Su-Yong Choi

Soon-Ja Choi

Eun-Ah Kim

Ho-Jae Lee

Jung-Hee Kim

The present invention relates to a novel geranyl flavonoid derivative with improved water-solubility or a pharmaceutically acceptable salt thereof, a method for preparing the same, and a method for treating cancer using the same. Particularly, the novel geranyl flavonoid derivative of the present invention inhibits the expression of STAT3 target protein by suppressing the phosphorylation of STAT3 (Signal Transducers and Activators of Transcription 3) protein, suggesting that it has cancer cell growth inhibiting effect in various cancer cell lines. Also, the compound of the invention has the effect of reducing the size and weight of a tumor significantly in vivo, so that the geranyl flavonoid derivative or the pharmaceutically acceptable salt thereof can be efficiently used for the treatment of cancer.

Geranyl flavonoid derivative with improved water solubility, a method for preparing the same, and a method for treating cancer using the same

The present invention relates to a pharmaceutical composition for preventing and treating cancer which comprises the extracts offruits, leaves, or stems, or the fractions thereof as active ingredients. The extracts offruits, leaves, or stems, or the fractions thereof, according to the present invention, suppress the activity of signal transducer and activator of transcription3 (STAT3) which plays an important role in the growth of a cancer cell line and in the immune function of the human body, and can thus be effectively used in the prevention and treatment of cancers such as colorectal cancer, stomach cancer, prostate cancer, breast cancer, renal cancer, liver cancer, brain tumor, lung cancer, uterine cancer, colorectal cancer, bladder cancer, or pancreatic cancer.

Composition for preventing or treating cancer containing extracts of artocarpus altilis fruits, leaves, or stems, or fractions thereof as active ingredients

A pharmaceutical composition for the prevention and treatment of inflammatory disease or asthma comprising the extract ofas an active ingredient. The extract ofof the present invention inhibited the increase of eosinophils in bronchoalveolar lavage fluid of the ovalbumin induced asthma animal model, had the activity of inhibiting the secretions of immunoglobulin and chemokine (Eotaxin) in bronchoalveolar lavage fluid and blood, and inhibited the secretions of NO and TNF-&#x3b1; in macrophages. Therefore, the extract ofof the present invention can be effectively used as an active ingredient of a pharmaceutical composition for the prevention and treatment of inflammatory disease or asthma, and of a health functional food for the prevention and improvement of inflammatory disease or asthma.

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The present invention relates to an anoikis-inducing agent comprising aextract, a tiarellic acid compound isolated therefrom or a pharmaceutically acceptable salt thereof, which is specific to cancer cells expressing a tumor-associated antigen L6 or a homolog thereof. Theextract, the tiarellic acid compound isolated therefrom or pharmaceutically acceptable salt thereof of the present invention leads to loss of cell adhesion to reduce cancer cell proliferation and exhibits the effect of inducing cell death in cancer cells expressing a tumor-associated antigen L6 or a homolog thereof, thereby being used for preventing and treating cancer diseases due to a tumor-associated antigen L6 or a homolog thereof.

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Daejeon, South Korea

Joongku Lee