Korea Research Institute of Bioscience and Biotechnology

Joong Ku Lee

Kyung Seop Ahn

Sei Ryang Oh

Hyeong Kyu Lee

Ok Kyoung Kwon

Doo Young Kim

Mi Jin Kim

Gui Hua Quan

Sang Ku Lee

Bo Young Park

Sang Ho Choi

Jung Hee Kim

Hyouk Joung

Sang Woo Lee

Hyung Won Ryu

In Sik Shin

Ji Won Park

So Young Kim

Gyoon Hee Han

Seung Hyung Kim

Byung Sun Min

Soon Ja Choi

Hang Jin

Joo Heon Kim

Wan Yi Li

Guang Hai Shen

Li Wan Yi

Hea Young Park

Gun Cheol Kim

Jin Hang

Fifit Juniarti

Rifatul Widjhati

Jin Hyub Paik

Eun Ah Kim

Gui Hua Natural Medicines Research Center Quan

Gyoon Hee 209-1702 Sinyeongtong Hyundai Apt Han

San Ku Lee

The present invention relates to a composition for suppressing chronic obstructive pulmonary disease (COPD) comprising aextract, a fraction thereof, or a compound isolated therefrom and, more particularly, to a pharmaceutical composition for preventing or treating COPD comprising aextract, a fraction thereof, or a compound isolated therefrom; a food composition for preventing or improving COPD, and the compound isolated therefrom. The composition comprising aextract, a fraction thereof, or a compound isolated therefrom, according to the present invention, is not toxic, suppresses the invasion of inflammatory cells into the bronchial tube of a COPD-induced animal model, and effectively suppresses the expression of CXCL-1, TNF-&#x3b1;, or MIP-2. In addition, due to the use of a safety-proven herbal drug as a raw material, the composition of the present invention can resolve various side-effects of existing therapeutic agents for COPD, chronic obstructive bronchitis, chronic bronchiolitis, emphysema, multiple sclerosis, and acute and chronic inflammation, and thus can be effectively used as a composition for preventing, treating and remedying COPD.

Pharmaceutical composition comprisingextract, fraction of same or compound separated from same for preventing or treating chronic obstructive pulmonary disease (COPD)

The present invention relates to a composition for preventing or treating asthma comprising aJ. Poiss. ex Franch extract or a fraction thereof. TheJ. Poiss. ex Franch extract or the fraction thereof according to the present invention does not exhibit toxicity, inhibits the generation of NO, IL-4, IL-5, and IL-13 and the generation of reactive oxygen species in the bronchial tubes, and has significantly induced the alleviation of airway hyperresponsiveness, inhibition of the infiltration of inflammatory cells into the bronchial tubes, and reduction of inflammatory cells in bronchoalveolar lavage fluid in an ovalbumin-induced asthma mouse model. In addition, theJ. Poiss. ex Franch extract or the fraction thereof according to the present invention effectively inhibits the secretion of immunoglobulins in serum, secretion of mucus in the bronchial tubes, and infiltration of inflammatory cells into lung tissue and thus can be usefully used as a safe preparation for preventing and treating asthma.

Pharmaceutical composition for preventing or treating asthma comprisingJ. Poiss. ex Franch extract or fraction thereof

The present invention relates to a pharmaceutical composition for preventing or treating inflammatory diseases or asthma comprising aextract or a fraction thereof as an active ingredient, and a health functional food and a feed additive for preventing or improving inflammatory diseases or asthma comprising the extract or the fraction as an active ingredient.

Pharmaceutical composition for preventing or treating inflammatory diseases or asthma, containing lagerstroemia ovalifolia extract or fraction thereof as active ingredient

The present invention relates to a composition comprising an extract ofgenus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract ofgenus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.

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Pharmaceutical composition comprising an extract of pseudolysimachion longifolium and the catalpol derivatives isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity

The present invention relates to a composition comprising an extract ofgenus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, antiallergic and anti-asthmatic activity. The extract ofgenus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.

The present invention relates to a composition comprising an extract of, and tiarellic acid isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract ofand the tiarellic acid isolated therefrom shows the inhibitory effect on the LTCrelease in vitro test and the suppressive effect on the IgE level and the cytokine (IL-4, IL-5 and IL-13) production, airway hyperresponsiveness, and leukocyte infiltration in OVA-induced asthmatic mice. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.

Growing community of inventors

Daejeon, South Korea

Joong Ku Lee