Daegu-gyeongbuk Medical Innovation Foundation

Korea Research Institute of Bioscience and Biotechnology

Daegu Gyeongbuk Institute of Science and Technology

National Cancer Center

Samsung Life Public Welfare Foundation

Joong-heui Cho

Sang Bum Kim

Hwan Geun Choi

So Young Kim

Jung Beom Son

Nam Doo Kim

Yi Kyung Ko

Seock Yong Kang

Seungyeon Lee

Sun-Hwa Lee

Jin-Hee Park

Eunhwa Ko

Dayea Kim

Sun Joo Lee

Seung Hoon Lee

Do-Hyun Nam

Jong Bae Park

Jae Hyun Bae

Hee Yoon Ryu

Sungchan Cho

Kyu-Sun Lee

Miri Choi

Eunmi Hong

Yunho Lee

Kweon Yu

Ja Wook Koo

Hyang-Sook Hoe

Tae-ho Jang

The present invention relates to a novel pyrrolo-pyrimidine derivative compound, a preparation method therefor, and a pharmaceutical composition comprising the same compound as an effective ingredient for preventing or treating a protein kinase-related disease. The compound represented by Chemical Formula 1 according to the present invention, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an effective ingredient has outstanding inhibitory activity against LRRK2 kinase and against phosphorylation in the NIH-3T3 cell line, which is an LRRK2-expressing cell line, and NCC01 and 448T cell lines, which are both derived from patients with brain tumors. Verified to have inhibitory activity against various protein kinases in addition to LRRK2, the compound can find effective applications in the treatment or prevention of protein kinase-related diseases. 

Pyrrolo-pyrimidine derivative compound, preparation method therefor, and pharmaceutical composition comprising same compound as effective ingredient for preventing or treating protein kinase-related disease

The present invention relates to a pyrrolo-pyridine derivative compound, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for the prevention or treatment of protein kinase-related diseases. A compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, has excellent inhibitory activity against various protein kinases including DYRK1A, and therefore, the pharmaceutical composition containing the same as an active ingredient can be favorably used in the treatment or prevention of protein kinase-related diseases. Particularly, the pharmaceutical composition can be effectively used in the prevention, treatment, or alleviation of Alzheimer's disease, dementia, or Alzheimer's dementia.

Pyrrolo-pyridine derivative compound, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of protein kinase-related diseases

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Daegu, South Korea

Joong-heui Cho