Other

Korea University Research and Business Foundation

Joon Bum Lee

Hae-Soo Kwak

Kwang Dae Hong

Jihun Seo

The present invention relates to an in-vivo bulking agent which can be used as a medicinal agent for prevention or treatment of at least one disease selected from the group consisting of urinary incontinence, fecal incontinence, and gastroesophageal reflux or as a filler for use in a plastic surgery procedure, and to a preparation method therefor. The in-vivo bulking agent can exhibit a bulking effect when injected into the body and particularly, is highly biocompatible because a first composition in which silicone particles are coated with a zwitterionic polymer having a surfactant property is introduced into a second composition, whereby the bulking agent can inhibit inflammatory reactions in vivo.

In vivo bulking agent, injection comprising same, and preparation method therefor

Disclosed is a method of removing residual enzymes when microencapsulating enzymes, and more particularly, for inactivating enzymes remaining in an uncapsulated form during microencapsulation of enzymes by treating dispersion fluid of microcapsules containing enzymes with ozone, together with removal of microorganisms harmful to human beings, where the ozone treatment is conducted for 1&#x2013;10 min with 1&#x2013;10 ppm of ozone generated from a UV lamp in a range from 150 to 200 nm wavelength.

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Chungcheongbuk-do, South Korea

Joon Bum Lee