Intocell, Inc.

Legochem Biosciences, Inc.

Y-biologics Inc.

Jongun Cho

Sunyoung Kim

Doohwan Jung

Taekyo Park

Sung Ho Woo

Hyang Sook Lee

Jaeho Lee

Suho Park

Beomseok Seo

Donghoon Seo

Sanghyeon Yun

Okku Park

Sangkwang Lee

Sena Kim

Minah Seol

Yun-Hee Park

Kyuman Oh

Hyangsook Lee

Youngun Kim

Hyunjin Kwon

Yunseo Chung

Yongzu Kim

Sungho Woo

Young Woo Park

Jae Eun Park

Hyun Ju Lee

Youngja Song

Hyun Mi Lee

Yunjung Ko

Eunjin Lee

Minju Lee

Yosup Rew

Jina Song

Jihyeon Ha

Eun-Young Shim

Provided are a compound including a cleavable linker, a use thereof, and an intermediate compound for preparing the same, and more particularly, the compound including a cleavable linker of the present invention may include an active agent (for example, a drug, a toxin, a ligand, a probe for detection, etc.) having a specific function or activity, a SOfunctional group which is capable of selectively releasing the active agent, and a functional group which triggers a chemical reaction, a physicochemical reaction and/or a biological reaction by external stimulation, and may further include a ligand (for example, oligopeptide, polypeptide, antibody, etc.) having binding specificity for a desired target receptor.

Compounds comprising cleavable linker and uses thereof

The present disclosure provides compounds and compositions comprising substituted benzodiazepines of the class of Formula I:

Substituted benzodiazepines as antibody-drug conjugates

The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-B7-H3 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind B7-H3, as well as methods of making and using these anti-B7-H3 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.

Antibody-drug conjugates comprising anti-B7-H3 antibodies

The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.

Benzodiazepine derivatives and uses thereof

The invention provides protein-active agent conjugates having an amino acid motif that can be recognized by an isoprenoid transferase. The invention also provides compositions containing the conjugates. The invention further provides methods for using the conjugates to deliver the active agent to a target cell, as well as methods for using the conjugates to treat a subject in need thereof (e.g., a subject in need of the active agent).

Antibody-active agent conjugates and methods of use

Growing community of inventors

Daejeon, South Korea

Jongun Cho