Advanced Protein Technologies Corporation

Seoul National University

Jong Won Yoon

Young Ha Song

Chul Soo Shin

Seon Min Jeon

Jong Gil Yoo

Kyung Ho Kim

Bo Mee Kim

Jeong Su Bang

Dae Hyuk Kweon

Jung Hee Moon

Ga Eun Lee

Eun Young Choi

Chui Soo Shin

Jin Kyung Kim

Heon Hak Lee

Ji Eun Kim

Ok Seon Jeon

Cheol Ho Jang

Yeon Ji Kim

Young Sun You

Young Sun Yoo

Seok Oh Moon

Disclosed is a method for, preventing, ameliorating or treating dementia by administering a composition containing 2'-fucosyllactose. 2′-FL ameliorates brain damage caused by amyloid beta and neuroinflammation by suppressing or preventing accumulation of the amyloid beta, thus being highly effective in preventing, ameliorating and treating dementia.

Composition for ameliorating or treating dementia containing 2'-fucosyllactose

Disclosed is a method for preventing or treating muscular atrophy or sarcopenia, the method comprising administering a composition comprising 2'-fucosyllactose (2′-FL) as an active ingredient to a subject in need thereof. The composition administered to the subject increases the expression of genes related to mitochondrial function enhancement and mitochondrial biosynthesis, and reduces the expression of atrogin-1 and MuRF1 genes, which are markers for muscular atrophy, thereby providing effects of strengthening muscles and preventing muscular atrophy or sarcopenia.

Method for ameliorating, preventing or treating muscular atrophy or sarcopenia by administering composition comprising 2'-fucosyllactose as active ingredient

Disclosed is a composition for promoting hair growth and ameliorating, preventing or treating hair loss containing 2'-fucosyllactose (2′-FL) as an active ingredient, and a method for promoting hair growth or ameliorating, preventing or treating hair loss, the method comprising administering to a subject in need thereof 2′-fucosyllactose. Treatment with a combination of testosterone and 2′-fucosyllactose increases hair gloss, increases hair length, reduces a hair loss area, enhances hair cuticles, increases the number and size of hair follicles, and improves expression of proteins and genes related to hair proliferation and growth, compared to treatment with testosterone alone, thus being applicable as a substance for various food and pharmaceutical compositions based on effects of promoting hair growth, improving hair loss, and ameliorating, preventing or treating hair loss.

Composition for promoting hair growth and improving, preventing, or treating hair loss containing 2'-fucosyllactose as an active ingredient

Disclosed is fucosyllactose having antiviral activity and inhibitory activity against viral infection, and a method for preventing or treating a viral infection by administering a composition including fucosyllactose as an active ingredient to a subject in need thereof. It was found that 2′-fucosyllactose and 3-fucosyllactose, which are human milk oligosaccharides (HMOs), have antiviral activity, and in particular, 3-fucosyllactose in vitro and in vivo exhibits much higher antiviral activity and inhibitory activity against viral infection compared to 2′-fucosyllactose and is thus useful as an antiviral agent.

Antiviral composition containing fucosyllactose as active ingredient

Disclosed are a food composition containing 2'-fucosyllactose and a pharmaceutical composition containing 2&#x2032;-fucosyllactose that are effective in ameliorating, preventing or treating various cerebro-cardiovascular diseases caused by thrombogenesis, and a method for ameliorating a cerebro-cardiovascular disease caused by a thrombus by administering a composition including 2&#x2032;-fucosyllactose (2&#x2032;-FL) to a subject in need thereof. The 2&#x2032;-fucosyllactose (2&#x2032;-FL) exhibits antagonistic (inhibitory) activity against CRP and collagen, which are agonists of platelets, and thus can be used to inhibit thrombogenesis due to abnormal platelet activity.

Food composition for ameliorating cerebrovascular diseases containing 2'- fucosyllactose and pharmaceutical composition for preventing or treating cerebrovascular diseases containing 2&#x2032;-fucosyllactose

Disclosed is a method for improving the productivity of 2'-fucosyllactose (2&#x2032;-FL) through enzymatic treatment. Lactose used as a substrate in the stationary phase during culture is degraded by treatment with a small amount of enzyme, the resulting glucose is consumed to produce guanosine diphosphate-L-fucose as a precursor of 2&#x2032;-fucosyllactose, and the use of lactose left after culture can be maximally utilized for the production of 2&#x2032;-fucosyllactose. As a result, it is possible to increase the productivity of 2&#x2032;-fucosyllactose in an economically efficient manner because additional glucose is not required while minimizing by-products.

Method for improving productivity of 2'-fucosyllactose through enzymatic treatment

Disclosed is a method for producing 2'-fucosyllactose from a recombinantsp. introduced with fucosyltransferase derived from. The recombinantsp. microorganism introduced with fucosyltransferase derived fromis capable of producing 2&#x2032;-fucosyllactose at a high concentration, high yield and high productivity.

Method of producing 2'-fucosyllactose using fucosyltransferase derived from Pseudopedobacter saltans

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Seongnam-si, South Korea

Jong Won Yoon