Korea University Research and Business Foundation

Korea Atomic Energy Research Institute

Korea Electric Power Corporation

Jong Seung Kim

Jonathan L Sessler

Min Goo Lee

Hyun Soo Park

Kune Woo Lee

Wang Kyu Choi

Miae Won

Won Zin Oh

Sung-Gil Chi

Moon Hwan Cho

Jong Kook Kim

Amit Sharma

Jin Yong Lee

Portable digital-to-analog converter

Disclosed is an anticancer prodrug that disturbs energy metabolism in cancer cells to overcome drug resistance. The anticancer prodrug has a structure including a pyruvate dehydrogenase kinase (PDK) inhibitor moiety, a mitochondrial targeting group, and an anthracycline moiety reversibly connected to the PDK inhibitor moiety and the targeting group.

Anticancer prodrug for overcoming drug resistance

Novel calix[4]arene dibenzo crown ethers useful to selectively extract cesium are represented by the formula: wherein R is a C.sub.1 -C.sub.10 normal alkyl, a phenyl or a methoxyphenyl, R' is hydrogen, p-tert-butyl or a C.sub.1 -C.sub.10 normal alkyl, R' is a C.sub.1 -C.sub.10 normal alkyl, and n is an integer of 0-2. The novel compound is prepared at high yields by introduction of benzene rings into the crown ether ring of calix[4]arene crown-6-ether. The calix[4]arene dibenzo crown ethers are superior in selective absorptivity for cesium ions by virtue of their 1,3-alternate conformational structure and thus, can be used as selective extractants able to separate cesium ions at a high efficiency.

Calix[4 ]arene dibenzo crown ethers, their preparation process and their

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Seoul, South Korea

Jong Seung Kim