Scripps Korea Antibody Institute

Abtlas Co., Ltd.

Jong Rip Choi

Dae Hee Kim

Byeong Doo Song

Jee Sun Yun

Hye In Kim

Hyo Jung Choi

Eung-Suk Lee

Song Yi Lee

Mee Hyun Jeoung

Suk Mook Lee

Min Kyoung Ki

Nara Tae

Min Jung Kim

Disclosed are an antibody to programmed death-ligand 1 (PD-L1) or an antigen-binding fragment thereof, a nucleic acid encoding the same, a vector including the nucleic acid, a cell transfected with the vector, a method of producing the antibody or the antigen-binding fragment thereof, a composition for preventing or treating cancer including the same, and a composition for combination therapy for preventing or treating cancer including the same.

Antibodies against programmed death-ligand 1 and uses thereof

The present invention relates to a method for constructing an Fv library based on a combination of proteins, a method of screening a desired antibody using the constructed Fv library, an Fv antibody screened by the screening method, and an Fv library constructed by the Fv library construction method. The Fv library of the present invention is based on a combination of proteins so that members thereof can be individually analyzed for their function. Moreover, the Fv library enables a desired Fv antibody to be screened without needing a target antigen preparation. In addition, the protein combination based Fv library makes it possible to significantly reduce the number of protein purification processes to thereby reduce costs and time, compared to conventional DNA-based libraries.

Protein combination-based FV library, and preparation method therefor

Provided is an antibody specifically binding to the CTLD (C-type lectin like domain) of clec14a (C-type lectin domain family 14, member A), a method for preparing the antibody, a composition for suppressing angiogenesis comprising the antibody, a method for suppressing angiogenesis by administering the antibody or the composition, a composition for preventing or treating cancer comprising the antibody, a method for treating cancer by administering the antibody or the composition, a composition for diagnosing cancer comprising the antibody, a kit for diagnosing cancer comprising the composition, a method for diagnosing cancer using the composition, a composition for suppressing angiogenesis comprising a material for inhibiting expression of clec14a, a kit for angiogenesis comprising the composition, a method for suppressing angiogenesis or treating cancer using the composition, and the use of the CTLD of clec14a as an epitope for an antibody suppressive of angiogenesis.

Antibody specific for CLEC14A and uses thereof

Growing community of inventors

Gangwon-do, South Korea

Jong Rip Choi