Samsung Electronics Co., Ltd.

Industry-University Cooperation Foundation Sogang University

Jong-myeon Park

Jeong-gun Lee

Beom-seok Lee

Yoon-kyoung Cho

Hun-joo Lee

Chang-eun Yoo

Yeon-jeong Kim

Hui-sung Moon

Byung-Chul Kim

Mi-jeong Song

Min-Seok Kim

Nam Huh

Jung-suk Yoo

Minseok Kim

Kwang Ho Cheong

Sung-woo Hong

Dong-kee Yi

Yoon-kyuong Cho

Min Seok S Kim

Sung-young Jeong

Young-Sun Lee

Kyung-hee Park

Beom Seok Lee

Jung-nam Lee

Jeong Gun Lee

Hyun-ju Kang

Tae-seok Sim

Ye-ryoung Yong

Jeong-Woo Choi

Dong-hyun Park

Jin-ho Oh

Do-gyoon Kim

Ga-hee Kim

Sang-hyun Peak

Kyung-yeon Han

Yoon Kyoung Cho

Yang-ui Lee

Jin-mi Oh

Han-sang Kim

Myoung-soon Kim

Jung-won Keum

Mi-jung Song

Ga-young Park

Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit.

Microfluidic device for simultaneously conducting multiple analyses

A photocleavable polymer comprising a photocleavable linker and a polymer having a functional group that binds to a protein, lipid, sugar of a cell, or any combination thereof, as well as a method of selectively lysing cells by incubating a sample comprising two or more cells with the photocleavable polymer to reversibly fix the cells; selectively irradiating the fixed cells or a target or non-target cell among the fixed cells to cleave the photocleavable polymer; and adding a cell lysis solution to selectively lyse the irradiated cells.

Method for reversible fixation or selective lysis of cell using photocleavable polymer

A microfluidic apparatus mounted on a rotation driving unit for inducing a fluid to flow due to a centrifugal force includes: a target chamber that houses a first fluid; a first chamber that houses a second fluid and is disposed closer to a rotation center of the microfluidic apparatus in a radius direction than the target chamber, the first chamber being connected to the target chamber by a first channel; a first valve that prevents a flow of the second fluid through the first channel; and a second chamber disposed closer to the rotation center in the radius direction than the target chamber and connected to the target chamber by a second channel, wherein the first fluid is transported to the second chamber by supplying the second fluid to the target chamber by the centrifugal force.

Microfluidic apparatus

Provided is a method of separating a rare cell from a sample comprising incubating a sample comprising a rare cell and a second cell with a particle comprising a moiety capable of binding to the rare cell to form a complex comprising the particle and the rare cell; applying the mixture to a medium having a density gradient; and centrifuging the mixture to separate the complex from the second cell.

Method of separating target cell in biological sample

Provided are an apparatus for filtering a fluid, the apparatus including a first flow channel and a second flow channel which are connected to each other in a fluid communicable manner via a filtration medium, and a method of isolating particles using the apparatus.

Apparatus for filtering fluid and methods of isolating particle using the same

Disclosed are sample analysis apparatus and methods. A sample analysis apparatus includes a first unit that rotates a microfluidic apparatus including: a chamber having a space accommodating a sample, a channel that provides a path through which the sample flows; and a valve that selectively opens and closes the channel, a valve driver that supplies energy, used to operate the valve, to the valve in a state of being separated from the microfluidic apparatus, a third unit that rotates the valve driver with respect to a common rotation axis with a rotation axis of the microfluidic apparatus and the third unit, and a control unit that controls the first and third units and the valve driver to supply energy to the valve while the microfluidic apparatus and the valve driver are being rotated at the same rotation speed.

Sample analysis methods and apparatuses and dynamic valve operation methods

Provided are nucleic acid structures suitable for reproducible Raman spectroscopy, methods of preparing the same, and methods of detecting a target material using the nucleic acid structures, whereby various target materials may be analyzed by using reproducible Raman spectroscopy.

Nucleic acid structure complex including nucleic acids, Raman-active molecules, and metal particles, method of preparing the same, and method of detecting target material by using the nucleic acid structure complex

Provided is method of diagnosing liver cancer in a subject, the method comprising contacting a sample from a subject with a substance that specifically binds to transmembrane emp24 domain trafficking protein 2 (TMED2), cluster of differentiation 43 (CD43), or any combination thereof on the surface of a microvesicle; and measuring the level of the substance bound to microvesicles in the sample; and related methods and compositions.

Composition for diagnosing liver cancer and methods of diagnosing liver cancer and obtaining information for diagnosing liver cancer

A microfluidic apparatus that is mounted on a rotation driver and induces a flow of a fluid according to a centrifugal force includes a lower structure having a microfluidic structure including a recovery chamber for accommodating a target material separated from a sample and a channel for forming an inflow path of the target material to the recovery chamber; an upper plate forming an upper wall of the recovery chamber and the channel; and a lid formed integrally to the upper plate and removable from the upper plate to open at least a part of a top of the recovery chamber.

Microfluidic apparatus with increased recovery rate of target material from a sample

A micro fluidic apparatus includes a sample chamber that divides a sample into a first fluid layer and a second fluid layer due to a centrifugal force; a first enriching unit a that receives the first fluid layer from the sample chamber, forms a first complex of a first fine particle and the first target material, and separates the first complex from the first fluid layer using a density difference; and a second enriching unit that receives the second fluid layer from the sample chamber, forms a second complex of a second fine particle and the second target material, and separates the second complex from the second fluid layer using a density difference.

Microfluidic apparatus and method of enriching target material in biological sample by using the same

Provided herein is a method of sequential and multiple immunostaining for detection of various antigens in the same specimens, which may be used for qualitative or quantitative analysis of proteins expressed, gene analysis, and morphological analysis even in specimens where only a small amount is available.

Method of sequential and multiple immunostaining for detection of various antigens in the same specimens

A microfluidic apparatus capable of being mounted on a rotation driving unit. When mounted on the rotation driving unit and rotated, a fluid flow is induced in the apparatus due to a centrifugal force. the microfluidic apparatus includes a sample supplying unit that comprises a sample chamber to house a sample and provides a fluid including a target material in which fine beads are bound to a target cell in the sample; a density-gradient separation unit that houses a density gradient material with a lower density than the target material, and receives the fluid from the sample supplying unit to separate the target material from the fluid based on a density difference; a fluid supplying channel connecting the sample supplying unit to the density-gradient separation unit to form a passage of the fluid; and a fluid supplying valve provided to the fluid supplying channel to selectively allow a flow of the fluid.

Microfluidic apparatus and method of enriching target cells by using the same

Provided are compositions, kits, and methods for separating cells including complexes of at least one type of linker capable of binding to an antibody or antigen binding fragment and a solid phase.

Compositions and kits for separating cells and method of separating cells using the same

Provided is a method of mixing fluids including introducing at least two kinds of fluids to a chamber of a substrate including a microchannel structure; and alternately rotating the substrate clockwise and counter-clockwise until the at least two kinds of fluids are mixed, wherein the rotation is changed from one direction to the opposite direction before a vortex created in the mixing chamber by the one direction rotation disappears.

Method of mixing at least two kinds of fluids in centrifugal micro-fluid treating substrate

Growing community of inventors

Seoul, South Korea

Jong-myeon Park