Korea Research Institute of Chemical Technology

Korea Research Institute of Bioscience and Biotechnology

Cj Corporation

Jeil Pharm. Co., Ltd.

Yang Ji Chemical Co., Ltd.

Han Wha Pharma Co., Ltd.

Jong Min Kim

Sung Soo Kim

Sang Dal Rhee

Won Hoon Jung

Hyae Gyeong Cheon

Jeong-Hyung Lee

Sung-eun Yoo

Seung Jun Kim

Jae Mok Lee

Kwang-Rok Kim

Jin Hee Ahn

Seung Kyu Kang

Sung Dae Park

Nam Gee Kim

Sung-Don Yang

Tae Wook Kim

Sung Jun Kim

Sung Il Lee

Seog Beom Song

Hyun Uk Jeong

Young Soo Jo

Koun Ho Lee

Hye Jung Kang

Sun Min Lee

Sun Chul Huh

Mi Suk Joung

Kyoung Rak Kim

Soon Ji Kwon

Eun Jung Yi

Sun Mee Kim

Kil Woong Mo

Hong Sik Moon

Se Mi Yu

Jae Min Lee

Chie Yeon Chough

Kyeoung Ah Kim

Jang Hyuk Lee

A novel substituted N-(pyrrolidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine and a use thereof as a Janus kinase (JAK) inhibitor are provided.

Substituted N-(pyrrolidine-3-yl)-7H-pyrrolo[2,3-D]pyrimidine-4-amine as janus kinase inhibitor

The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and prevention of disorders modulated by PPARs, i.e., metabolic syndromes such as diabetes, obesity, arteriosclerosis, hyperlipidemia, hyperinsulinism and hypertension, inflammatory diseases such as osteoporosis, liver cirrhosis and asthma, and cancer.

Indene derivatives and process for the preparation thereof

An indene derivative for selectively modulating the activities of peroxisome proliferator activated receptors (PPARs) having the following formula (I): wherein, or phenyl; being each unsubstituted or substituted with one or more substituents selected from the group consisting of halogen, CN, NH, NO, OR, phenyloxy, Calkyl, and Ccycloalkyl; and

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Anyang-si, South Korea

Jong Min Kim