Baxter International Inc.

Edwards Lifesciences Corporation

Baxter Healthcare Sa

Jong H Wang

Stefan G Schreck

Alain F Carpentier

Sophie M Carpentier

Victor S Packham

Lillian J Quintero

Siddharth Desai

The present invention includes systems and methods for determining the viscosity of a fluid within a fluid flow path. Such method may comprise flowing fluid through the fluid flow path and past a fixed flow restriction therein. The method may also comprise first sensing of a fluid pressure within the fluid flow path at a selected location upstream of the flow restriction. The method may also include limiting fluid flow in the fluid flow path upstream of such selected location. The method may further comprise second sensing of a fluid pressure within the fluid flow path at such selected location after such limiting. Such method includes determining the viscosity of the fluid based, at least in part, on any pressure difference from such first and second sensing.

System and method for measuring liquid viscosity in a fluid delivery system

An apparatus for treating fixed biological tissue to inhibit calcification of the biological tissue following implantation thereof in a mammalian body. The apparatus includes a container for placing the biological tissue in contact with a treatment solution, structure to induce relative tissue/solution movement, and structure to heat the solution. The relative movement may be induced by shaking a container in which the tissue is immersed in the treatment solution, or by stirring the solution within the container. The movement may also be induced by flowing a treatment solution past the tissue to be treated. The tissue may be free to move in the treatment container, or may be restrained from gross movements. The flow may be part of a circulation system having a reservoir, with a heater being provided to heat the treatment solution in the reservoir. Alternatively, a treatment apparatus, including a fluid circulation system if desired, may be enclosed in an incubator. The tissue may be mounted in a planar configuration generally parallel to the direction of fluid flow. A flow column having a plurality of sections divided by perforated baffles may be used to treat multiple tissues at once.

Apparatuses and methods for treating biological tissue to mitigate calcification

Apparatuses for treating biological tissue to mitigate calcification

A method for treating fixed biological tissue inhibits calcification of the biological tissue following implantation thereof in a mammalian body. The method includes placing the biological tissue in contact with a treatment solution, inducing relative tissue/solution movement, and heating the solution. The relative movement may be induced by shaking a container in which the tissue is immersed in the treatment solution, or by stirring the solution within the container. The movement may also be induced by flowing a treatment solution past the tissue to be treated. The tissue may be free to move in the treatment container, or may be restrained from gross movements. The flow may be part of a circulation system having a reservoir, with a heater being provided to heat the treatment solution in the reservoir. Alternatively, a treatment apparatus, including a fluid circulation system if desired, may be enclosed in an incubator. The tissue may be mounted in a planar configuration generally parallel to the direction of fluid flow. A flow column having a plurality of sections divided by perforated baffles may be used to treat multiple tissues at once.

Methods and apparatuses for treating biological tissue to mitigate

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Rancho Palos Verdes, CA, United States of America

Jong H Wang