Korea Research Institute of Chemical Technology

St Pharm Co., Ltd.

Jong Chan Son

Ill Young Lee

Michael L Mitchell

Hongyan Guo

Choung U Kim

Lianhong Xu

Bong Jin Kim

Jae Hak Kim

Sang Ho Lee

Thorsten A Kirschberg

Steven S Pfeiffer

Chong Ock Lee

Kyungjin Kim

Chang Soo Yun

Chong-Kyo Lee

Uk-Il Kim

Stacey Heumann

Hwa Jung Nam

Hong Suk Shin

Gerry Rhodes

Provided is a novel pyrrolopyridine compound represented by Chemical Formula I, a racemate or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof; and to a method for preparing the same. A compound represented by Chemical Formula I shows high selectivity and antiviral activity against human immunodeficiency virus (HIV), with low toxicity; therefore, it is useful as a therapeutic agent for viral infection, in particular, HIV infection.

Pyrrolopyridine derivative, method for producing same, and use thereof

The present invention relates to a pyrrolopyridine derivative represented by the Chemical Formula I, and a racemate or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and relates to an antiviral composition including the same as an active ingredient. The compound of the Chemical Formula I has excellent antiviral activity and selectivity for wild type and resistant HIV-1, and thereby is useful as a therapeutic agent for acquired immune deficiency syndrome (AIDS).

Antiviral pyrrolopyridine derivatives and method for preparing the same

The invention is related to compounds of Formula (I): or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.

Pyrimidine derivatives as HIV reverse transcriptase inhibitors

Compounds of Formula (I): can be prepared by a multi-step process from compounds of Formula (II): wherein G is Cl, Br or I.

Processes for preparing HIV reverse transcriptase inhibitors

The invention is related to pyrimidine-2,4-dione HIV reverse transcriptase inhibitors of Formula (I), (II), or (III): or a pharmaceutically acceptable salt, thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.

Pyrimidine-2,4-dione HIV reverse transcriptase inhibitors

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Daejeon, South Korea

Jong Chan Son