Hyundai Motor Company

National Cancer Center

Ktc Co., Ltd.

Seoul National University

Samsung Life Public Welfare Foundation

Hyundai Mobis Corporation

Daegu-gyeongbuk Medical Innovation Foundation

The Asan Foundation, University of Ulsan Foundation for Industry Cooperation

Jong Bae Park

June Soo Park

Hyuk Sub Kwon

Sang Bum Kim

Young Oh

Byoung Suk Ahn

Ji Eun Kim

Seung Hoon Lee

Hwan Geun Choi

Tae Hoon Kim

Ho Joong Lee

So Young Kim

Junho Chung

Jung Beom Son

Do-Hyun Nam

Nam Doo Kim

Hyori Kim

Yi Kyung Ko

Hwa Kyoung Lee

Soo Youl Kim

Tae-Won Lee

Junyeong Jin

Heon Yoo

Seock Yong Kang

In Heum Park

Seungyeon Lee

Eunhwa Ko

Jin-Hee Park

Eugene C Yi

Sun-Hwa Lee

Jae Hyun Bae

Dayea Kim

Sun Joo Lee

Joong-heui Cho

Hyon Chol Jang

Eunmi Hong

Ki Seok Ko

Donghee Lee

Jeong Geun Kim

Hyun Mug Ji

Young Ho Lim

Eun Kyoung Park

Jung Pil Jung

Hea Jin Kim

Hee Jin Kwak

Tae-ho Jang

Yunho Lee

The present disclosure relates to a pharmaceutical composition comprising a combination of anticancer agents, capable of creating a synergistic effect when co-administer in the treatment of cancer, and more specifically, the present invention suggests anticancer agenst capable of creating a synergistic effect when co-administered with gossypol and phenformin. The anticancer agents selected as said anticancer agents in the present disclosure are sorafenib, vemurafenib, irinotecan, cisplatin, paclitaxel, and doxorubicin, and each of the aforementioned anticancer agent, when co-administered as a triple-drug combination with gossypol and phenformin can provide a significant synergistic effect in terms of the effect of suppressing the proliferation of cancer and killing cancer cell, compared to each mono-drug treatment group and a dual-drug treatment group of gossypol+phenformin.

Pharmaceutical composition for preventing or treating cancer, comprising gossypol, phenformin, and anticancer agent

The present invention relates to an anti-ROS1 antibody improved in specificity for ROS1 and a use thereof and, more particularly, provides an anti-ROS1 antibody or an antigen-binding fragment thereof and a use thereof in cancer diagnosis.

Anti-ROS1 antibody and use thereof

An iris image acquisition system for expanding an iris recognition range is proposed. The iris image acquisition system for expanding the iris recognition range enables that a direction, zoom, and focusing of an iris photographing camera for photographing an iris image of a distant subject are controlled quickly and easily without high-level information processing and arithmetic processing.

System for acquisiting iris image for enlarging iris acquisition range

Disclosed herein is a method of detecting a vehicle speed. The method includes receiving a first vehicle image photographed by a camera at a first time; identifying an area occupied by the license plate from the first vehicle image and extracting a first number; receiving a second vehicle image photographed by the camera at a second time; identifying an area occupied by the license plate from the second vehicle image and extracting a second number; comparing the first number with the second number to determine whether the first number is equal to the second number; deciding an actual size of the number of plate; calculating a distance between the vehicle and the camera at first and second times; and calculating a vehicle speed.

Method of detecting speed using difference of distance between object and monitoring camera

The present invention relates to a novel pyrrolo-pyrimidine derivative compound, a preparation method therefor, and a pharmaceutical composition comprising the same compound as an effective ingredient for preventing or treating a protein kinase-related disease. The compound represented by Chemical Formula 1 according to the present invention, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an effective ingredient has outstanding inhibitory activity against LRRK2 kinase and against phosphorylation in the NIH-3T3 cell line, which is an LRRK2-expressing cell line, and NCC01 and 448T cell lines, which are both derived from patients with brain tumors. Verified to have inhibitory activity against various protein kinases in addition to LRRK2, the compound can find effective applications in the treatment or prevention of protein kinase-related diseases. 

Pyrrolo-pyrimidine derivative compound, preparation method therefor, and pharmaceutical composition comprising same compound as effective ingredient for preventing or treating protein kinase-related disease

An overhead console apparatus of a vehicle may include a housing provided in a front portion of an indoor ceiling of the vehicle and having a downwardly open accommodation portion formed therein, a glass case accommodated in the accommodation portion and rotatably coupled to the housing around a rotating shaft that may be formed on a front side surface thereof in a traverse direction of the vehicle, a conversation mirror accommodated in a rear portion of the glass case in the accommodation portion, and a switch slidably provided on a side of the glass case to selectively couple the glass case and the conversation mirror, wherein when the switch moves in a first direction, the conversation mirror may be integrally coupled to the glass case, and when the switch moves in a second direction, the conversation mirror may be separated from the glass case.

Overhead console of vehicle

Disclosed is a radiation sensitivity-enhancing composition in which a microRNA-21 inhibitor acts as an active ingredient. The microRNA-21 inhibitor is an antisense nucleic acid molecule binding complementarily to microRNA-21. The composition can be administered to a patient in conjunction with irradiation. The inhibitor can act as a radiosensitizer, enhancing the therapeutic effect of such irradiation on cancer high in microRNA-21 expression level, particularly, glioma.

Composition containing microRNA-21 inhibitor for enhancing radiation sensitivity

A head lamp for a vehicle is provided, which includes a reflector for reflecting light emitted from a light source, a reflection plate for collecting the light reflected from the reflector in an upward direction, a micro-reflection module provided over the reflector to tilt and reflect the light collected by the reflection plate at a desired angle, and an optical lens for irradiating the light reflected from the micro-reflector onto a road surface. The head lamp can implement various beam patterns in accordance with road and surrounding circumferences, and irradiate vehicle information onto a road surface, thereby reducing the dazzle of other drivers of opposite vehicles and improving the field of vision of the driver to improve the safety and convenience.

Head lamp for vehicle

An overhead console of the vehicle may include a housing provided on a front portion of an indoor ceiling of the vehicle and having a downwardly open accommodation portion formed therein, a glass case accommodated in the accommodation portion and rotatably coupled to the housing around a rotating shaft that may be formed on a front side surface of the housing in a traverse direction of the vehicle, and a conversation mirror rotatably coupled with the housing in the accommodation portion and selectively engaged with a rear portion of the glass case.

Growing community of inventors

Seoul, South Korea

Jong Bae Park