Sandoz Gmbh

Novartis Ag

Sandoz Pharm. Corp.

Jones W Fong

Thomas Kissel

David Bodmer

Hawkins V Maulding

Oskar Nagele

Jane E Pearson

The invention discloses microparticles comprising a polypeptide, preferably somatostatin or an analog or derivative thereof, more preferably octreotide, in a polymeric matrix, preferably poly(lactide-co-glycolide) glucose. The invention also discloses sustained release formulations containing said microparticles and the use of said formulations in treating acromegaly and breast cancer.

Sustained release formulations of water soluble peptides

The invention discloses microparticles comprising a polypeptide, preferably somatostatin or an analog or derivative thereof, more preferably octreotide, in a polymeric matrix, preferably poly(lactide-co-glycolide)glucose. The invention also discloses sustained release formulations containing said microparticles and the use of said formulations in treating acromegaly and breast cancer.

Microspheres, prepared by solvent removal from an oil-in-water emulsion using carboxylic acid salt surfactant, e.g., sodium oleate as the emulsifier.

Process for preparation of microspheres

This invention provides for the production of microspheres in an oil-in-water emulsion process using an emulsifier, whereby solvent removal from the oil phase allows for isolation of discrete microspheres, wherein the release rate of a core material is modified by the use of an alkaline agent, e.g. sodium hydroxide, during the preparation of the microspheres.

Process for preparation of microspheres and modification of release rate

Microspheres, prepared by the low-temperature e.g., -40.degree. to -100.degree. C., phase separation of a polymer and a core material.

Growing community of inventors

Parsippany, NJ, United States of America

Jones W Fong