Abbvie Inc.

Jonathon Green

Jeffrey Y Pan

Stanislaw Kantor

Jeffrey A Olson

Jonathan D Trumbull

Gary A Gintant

Gilbert J Diaz

Zhi Su

Jeffrey Yen Pan

A rapid and efficient method and apparatus for detecting electrophysiologic, proarrhythmic, contractile, and other effects of substances such as compounds and drugs in native cellular cardiac preparations, the preparations representing an integrated cell-based pharmacologic response is disclosed. More specifically, a method to (1) rapidly and efficiently detect and verify the effects of chemicals, compounds and drugs on cardiac repolarization, contractility, and excitability using optically based techniques and customized simulation protocols, and (2) rapidly and efficiently screen and select compounds for electrophysiologic and proarrhythmic effects on cardiac myocytes is disclosed.

High throughput, optical method and system for determining the effect of a test substance on non-contiguous living cells

Growing community of inventors

Elgin, IL, United States of America

Jonathon Green