Dana-farber-cancer Institute Inc.

University of Florida Research Foundation Inc

Long, Jonathan, Z.

Spiegelman, Bruce, M.

Jonathan Z Long

Bruce M Spiegelman

Theodore M Kamenecka

Patrick Griffin

Hua Lin

Rajesh R Rao

The present invention relates to methods for identifying, assessing, preventing, and treating metabolic disorders and modulating metabolic processes using PM20D1 and N-lipidated amino acids.

Methods for identification, assessment, prevention, and treatment of metabolic disorders using PM20D1 and N-lipidated amino acids

Uncoupling of respiration is a well-recognized process that increases respiration and heat production in cells. Provided herein are chemical uncouplers of respiration that are compounds of Formula (I). Also provided are methods for preventing or treating metabolic disorders and modulating metabolic processes using compound of Formula (I).

Chemical uncouplers of respiration and methods of use thereof

The invention provides compositions and methods for regulating thermogenesis and muscle inflammation through modulation of Metrnl and/or Metrn activity and/or expression. Also provided are methods for preventing or treating metabolic disorders and muscle inflammation disorders in a subject through modulation of Metrnl and/or Metrn activity and/or expression. Further provided are methods for identifying compounds that are capable of treating metabolic disorders and muscle inflammation disorders by modulating Metrnl and/or Metrn activity and/or expression.

Compositions and methods for regulating thermogenesis and muscle inflammation using metrnl and metrn

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Menlo Park, CA, United States of America

Jonathan Z Long